Summary of Study ST000918
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000634. The data can be accessed directly via it's Project DOI: 10.21228/M8QM3R This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST000918 |
Study Title | Plasma metabolic fingerprint for breast cancer (MS) - part I |
Study Type | control - case |
Study Summary | Breast cancer is a highly heterogeneous disease associated with metabolic reprogramming. The shifts in the metabolome caused by breast cancer still lack data from Latin populations of Hispanic origin. In this pilot study, metabolomic and lipidomic approaches were performed to establish a plasma metabolic fingerprint of Colombian Hispanic women with breast cancer. NMR, GC-MS and LC-MS datasets were combined and compared. Statistics showed discrimination between breast cancer and healthy subjects on all analytical platforms. |
Institute | Universidad de los Andes, Colombia |
Department | Chemistry |
Last Name | Cala |
First Name | Monica |
Address | Cra. 1 #18a-12 |
mp.cala10@uniandes.edu.co | |
Phone | +571 3394949 |
Submit Date | 2017-12-29 |
Num Groups | 2 |
Total Subjects | 58 |
Analysis Type Detail | GC-MS/LC-MS |
Release Date | 2018-02-07 |
Release Version | 1 |
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Sample Preparation:
Sampleprep ID: | SP000963 |
Sampleprep Summary: | 40 µL of plasma was deproteinized with cold acetonitrile (1:3,−20 °C), followed by a two-step derivatization: (i) methoximation with O-Methoxyamine hydrochloride in pyridine (15 mg/mL, room temperature, 16 h) followed by (ii) silylation with BSTFA containing 1% TMCS (70 °C, 1 h). |
Processing Method: | Protein precipitation followed by metabolite extraction |
Processing Storage Conditions: | On ice |
Extraction Method: | Acetonitrile |
Sample Derivatization: | Methoximation and silylation |