Summary of Study ST003205
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001998. The data can be accessed directly via it's Project DOI: 10.21228/M8G143 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST003205 |
| Study Title | Metabolic profile evolution in relapsed/refractory B-NHL patients treated with CD19.CAR-T cell therapy and implications in clinical outcome |
| Study Type | NMR Metabolomic |
| Study Summary | Plasma metabolomics analysis was performed on 44 patients with relapsed/refractory B-cell non Hodgkin lymphoma (r/r/B-NHL) infused with approved CD19.CAR-T cell products at the time of pre-lymphodepletion (PLD) and at day +1, +7, and +30 after CAR-T cell infusion. At the PLD time point, a metabolic profile characterized by high lipoproteins and lactate and low glucose contributed to poor outcome prediction in association with high lactate dehydrogenase levels. At day+1, higher plasma levels of lipid metabolism products and lower glucose and glycoproteins levels were observed in tisa-cel- compared to axi-cel-treated patients. At day+30, a higher content of lactate, as well as phenylalanine/tryptophan amino acids which represent the precursors of the key players of myeloid derived suppressor cells were found in patients who relapsed over time compared to patients who maintained complete remission until 1-year. Our data show complex metabolomic changes that track the evolution of the disease and drug activity in the first 30 days of CAR-T cell therapy. Notably, specific metabolic signatures at PLD and day+30, together with a day+30 metabolic profile related to myeloid immunosuppression, are associated with poor outcome. |
| Institute | UNIVERSITY OF SALENTO |
| Department | D.i.S.T.e.B.A. |
| Laboratory | General and Inorganic Chemistry |
| Last Name | FANIZZI |
| First Name | FRANCESCO PAOLO |
| Address | Prov.Le Lecce-Monteroni - Centro Ecotekne |
| fp.fanizzi@unisalento.it | |
| Phone | ++39-0832-299265 |
| Submit Date | 2024-05-02 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | fid |
| Analysis Type Detail | NMR |
| Release Date | 2024-06-07 |
| Release Version | 1 |
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Subject:
| Subject ID: | SU003324 |
| Subject Type: | Human |
| Subject Species: | Homo sapiens |
| Taxonomy ID: | 9606 |
