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MB Sample ID: SA027832
| Local Sample ID: | S_66 |
| Subject ID: | SU000552 |
| Subject Type: | Serum |
| Subject Species: | Mus musculus |
| Taxonomy ID: | 10090 |
| Genotype Strain: | C57BLKsJ-db/db (disease model) and C57BLKsJ wild type (wild type) |
| Age Or Age Range: | 14 weeks; drug administration since the 5th week |
| Weight Or Weight Range: | 37-58 g for db/db mice; 18-25 g for wild type mice |
| Gender: | Male |
| Species Group: | Mammal |
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Treatment:
| Treatment ID: | TR000566 |
| Treatment Summary: | C57BLKsJ-db/db mice were classified randomly into 8 groups. Seven groups were with 9~10 mice for each and one group with 4 mice. Mice were treated with DG extract (5 g/Kg), DG extract (1 g/Kg), KK01 (50 mg/Kg), KK01 (20 mg/Kg), metformin (5 mg/Kg); rotaglitazone (5 mg/Kg); and saline. Group treated with KK01(20 mg/Kg) and the group with 4 mice treated by saline were used intraperitoneal injection. Other groups were in intragastric administration. Also, a group with ten C57BLKsJ mice fedding with saline was used as healthy control. The drug administration were started with the 5th week of the age and lasted for 9 weeks. |
| Treatment Route: | Intragastric administration for all except for group of KK01 low-dose (20 mg/Kg), and 4 db/db mice treated with saline which were treated by intraperitoneal injection. |
| Treatment Dose: | 5 g/Kg for DG high dose; 1 g/Kg for DG low dose; 50 mg/Kg for KK01 high dose; 20 mg/Kg (i.p.) for KK01 low dose; 5 mg/Kg for metformin, 5 mg /Kg for rosiglitazone |
| Treatment Dosevolume: | 0.5 mL |
| Treatment Doseduration: | 9 weeks |
| Treatment Vehicle: | saline |
| Animal Fasting: | Over night |
| Animal Endp Tissue Coll List: | liver, kidney, brain, white fat, brown fat, pancreas |
