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MB Sample ID: SA081225
Local Sample ID: | 71 |
Subject ID: | SU001237 |
Subject Type: | Mammal |
Subject Species: | Mus musculus |
Taxonomy ID: | 10090 |
Gender: | Female |
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Treatment:
Treatment ID: | TR001252 |
Treatment Summary: | Triple-mutant (TKO) mice (p53 LSL-R172H/+ Dicer1 flox/flox Pten flox/flox Amhr2 cre/+) were generated by mating p53 LSL-R172H/+ Dicer1 flox/flox Pten flox/flox female with Dicer1 flox/flox Pten flox/flox Amhr2 cre/+ male mice. Serum samples were collected from TKO mice at different stages of tumor progression: from premalignant stage to early stage to advanced stage. Precursor lesions are fallopian tubes at premalignant stage, when no tumors are yet present. TKO mice with precursor (i.e. premalignant stage) lesions in the fallopian tubes are referred to as “TKO-Pre”; TKO-ET (early tumor) are TKO mice with early-stage tumors in the fallopian tube without evidence of metastasis; TKO-AT (advanced-stage tumor) are TKO mice with ovarian and peritoneal metastases accompanied by ascites; and TKO-ctrl are control mice (p53 LSL-R172H/+ Dicer1 flox/flox Pten flox/flox), which have the same genetic background as TKO mice but develop no tumors. All TKO mice developed high-grade serous carcinoma (HGSC, i.e. high-grade serous ovarian cancer). |