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MB Sample ID: SA094613
Local Sample ID: | HFD-BPA12 |
Subject ID: | SU001383 |
Subject Type: | Mammal |
Subject Species: | Rattus norvegicus |
Taxonomy ID: | 10116 |
Genotype Strain: | Sprague Dawley |
Age Or Age Range: | 240 days |
Gender: | Male |
Animal Animal Supplier: | Harlan |
Animal Housing: | polycarbonate-free caging |
Animal Light Cycle: | 14-hr light and 10-hr dark |
Animal Feed: | Phytoestrogen Reduced II 18-5 (Ziegler Bros, Inc) or D09100301 (Research Diets, Inc) |
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Treatment:
Treatment ID: | TR001398 |
Treatment Summary: | Neonatal rats were treated with vehicle (sesame oil) or bisphenol A (BPA; 50 µg/kg dissolved in sesame oil) orally via pipette tip on post-natal days 1, 3, and 5. Littermates were randomly assigned to the treatment groups. BPA was obtained from the National Institute of Environmental Health Sciences (NIEHS). The dose and route of administration recapitulates human exposure to BPA. At day 180, adult rats in both treatment groups were fed a diet high in fat (40% kcal), fructose (20% kcal) and cholesterol (2%) (Western-style diet) for 60 days (D09100301, Research Diets, Inc). Rats were fasted overnight prior to tissue collection. |