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MB Sample ID: SA097884
Local Sample ID: | AR408_control_AA_THR1plus4_3pt2 |
Subject ID: | SU001422 |
Subject Type: | Mammal |
Subject Species: | Mus musculus |
Taxonomy ID: | 10090 |
Genotype Strain: | C57Bl/6JMarp |
Age Or Age Range: | 7 to 12 weeks |
Gender: | Male |
Animal Animal Supplier: | Monash University Animal Research Platform, Clayton, AUS |
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Treatment:
Treatment ID: | TR001437 |
Treatment Summary: | Male mice aged 7 weeks upon arrival, were acclimated to the local housing facility (12-12h light-dark cycle, 22-24°C) for one week prior to experimentation and were fed standard rodent chow (8720610, Barastoc, AUS). Following acclimation, mice were administered a total of 5E+11 virus particles per mouse via the tail vein. For the negative control (NC): 5E+11 GFP-AAV; and for the THR1/4 overexpression studies mice were administered 2.5E+11 virus particles each of yTHR1-AAV and yTHR4-AAV. One week following this time, the dietary intervention was initiated. In these studies, the low threonine diet (SF18-066, Specialty Feeds AUS) contained homoserine, the substrate of THR1. The corresponding control diet was SF17-177 (Specialty Feeds AUS). |