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MB Sample ID: SA098977
Local Sample ID: | Con007 |
Subject ID: | SU001435 |
Subject Type: | Mammal |
Subject Species: | Mus musculus |
Taxonomy ID: | 10090 |
Genotype Strain: | C57BL6J |
Age Or Age Range: | 18-20 weeks |
Weight Or Weight Range: | 20-30g |
Gender: | Male and female |
Animal Animal Supplier: | Jackson Labs |
Animal Housing: | 5/cage |
Animal Light Cycle: | 12h |
Animal Feed: | Ad libitum. Control mice received custom casein-diet. Chronic kidney disease was induced by supplementing casein-based diet with 0.15% adenine |
Animal Water: | Ad libitum |
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Treatment:
Treatment ID: | TR001450 |
Treatment Summary: | We utilized an established adenine-diet model to induce CKD in mice. Mice were assigned to a casein-based chow diet for 7 days, followed by induction of renal tubular injury by supplementing the diet with 0.2% adenine for 7 days, and were subsequently maintained on a 0.15% adenine diet for 7 more weeks. CKD mice were then placed back on control casein diet for 2 weeks to prior to euthanasia and terminal experiments. Control mice received casein diet for the duration of the study. |
Animal Anesthesia: | Ketamine/Xylazine |
Animal Endp Euthanasia: | Ketamine/Xylazine |