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MB Sample ID: SA171976
Local Sample ID: | S35 |
Subject ID: | SU001925 |
Subject Type: | Mammal |
Subject Species: | Mus musculus |
Taxonomy ID: | 10090 |
Genotype Strain: | APPSwe/PS1ΔE9 (APP/PSEN1) |
Age Or Age Range: | 12 month |
Gender: | Male and female |
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Treatment:
Treatment ID: | TR001937 |
Treatment Summary: | Briefly, at 2-months of age, standard lab chow (Purina 5001, 4% kcal/fat) was replaced with either HFD in which 60% kcal are derived from lard, 20% from carbohydrate and 20% from protein, or low-fat diet (LFD) control in which 10% kcal are derived from lard and additional calories are derived from corn starch, with 70% from carbohydrates and 20% from protein.33 For the reversal group (REV), a subset of mice on the HFD was provided with a LFD, at 9.5 months of age, for the study duration.33 All other mice were maintained on their original experimental diets until the end of the study, which was an additional 10 weeks. |