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MB Sample ID: SA177790

Local Sample ID:	CZ.0179.001_1
Subject ID:	SU001996
Subject Type:	Human
Subject Species:	Homo sapiens
Taxonomy ID:	9606
Gender:	Male and female

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Treatment:

Treatment ID:	TR002008
Treatment Summary:	Details of personal benzene exposure assessment have been reported previously. [14] In brief, individual exposure was monitored by organic vapor passive dosimetry badges (3M no. 3500. St.Paul. Minnesota), which were worn by each worker for a full shift on 5 separate days for a 1–2 week period prior to blood collection. Badges were analyzed by gas chromatography (GC) with flame ionization detection for benzene, toluene, and xylene. Average exposure was calculated for each compound as the geometric mean of the five air measurements. In this study, we focus on control workers with no benzene exposure, lower (relative) exposures (<20ppm) and high exposure (>20ppm) Due to benzene levels exceeding the current OSHA time-weighted exposure limit of 1 ppma for all exposed workers, the median exposure of 20 ppm was used to classify low- and high-exposed workers to identify exposure-associated metabolic changes. For each m/z feature, peak intensity was log2 transformed to test for association with benzene across the categories of exposure, which included controls, low exposed (<20 ppma) and high exposed (≥20 ppma), defined as a continuous variable (control=0; < 20 ppma= 1; ≥20 ppma= 2)

Treatment ID:

TR002008

Treatment Summary:

Details of personal benzene exposure assessment have been reported previously. [14] In brief, individual exposure was monitored by organic vapor passive dosimetry badges (3M no. 3500. St.Paul. Minnesota), which were worn by each worker for a full shift on 5 separate days for a 1–2 week period prior to blood collection. Badges were analyzed by gas chromatography (GC) with flame ionization detection for benzene, toluene, and xylene. Average exposure was calculated for each compound as the geometric mean of the five air measurements. In this study, we focus on control workers with no benzene exposure, lower (relative) exposures (<20ppm) and high exposure (>20ppm) Due to benzene levels exceeding the current OSHA time-weighted exposure limit of 1 ppma for all exposed workers, the median exposure of 20 ppm was used to classify low- and high-exposed workers to identify exposure-associated metabolic changes. For each m/z feature, peak intensity was log2 transformed to test for association with benzene across the categories of exposure, which included controls, low exposed (<20 ppma) and high exposed (≥20 ppma), defined as a continuous variable (control=0; < 20 ppma= 1; ≥20 ppma= 2)