Metabolomics Workbench : NIH Data Repository

MB Sample ID: SA211341

Local Sample ID:	ES250414-PDA1
Subject ID:	SU002288
Subject Type:	Mammal
Subject Species:	Mus musculus
Taxonomy ID:	10090
Genotype Strain:	C57BL/6 (WT); LSL-KrasG12D/+ - p48Cre/+; LSL-KrasG12/D+; LSL-Tpr53R172H/+; Pdx-1-Cre
Age Or Age Range:	1.5 to 9 months
Animal Light Cycle:	12h light/dark cycles (7.00 AM lights on)
Animal Feed:	ad libitum
Animal Water:	ad libitum
Animal Inclusion Criteria:	Healthy animails
Species Group:	C57BL/6 (WT); LSL-KrasG12D/+ - p48Cre/+; LSL-KrasG12/D+; LSL-Tpr53R172H/+; Pdx-1-Cre

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Treatment:

Treatment ID:	TR002300
Treatment Summary:	The control group (N, normal tissue, n=7) comprised animals that did not develop lesions or tumors (C57BL/6 wt mice); the pancreatitis group (Pt, n=6) comprised C57BL/6 wt mice in which acute pancreatitis was induced by six hourly intraperitoneal 50 ug/kg caerulein (Sigma-Aldrich, Dorset, UK) injections; the low grade lesion group (LG, n=5) comprised 4-month old KC (LSL-KrasG12D/+ - p48Cre/+) mice with predominant LG PanIN lesions (mPanIN 1 and 1A); the high grade lesion group (HG, n=7) comprised 9-month old KC mice with predominant HG PanIN lesions (mPanIN 2 and 3); the spontaneous pancreatic ductal adenocarcinoma (PDA, n=6) and sarcomatoid (Sarc., n=9) groups corresponded to 3-6 month old KPC (LSL-KrasG12/D+;LSL-Tpr53R172H/+;Pdx-1-Cre) mice. Tumors were studied when they were less than 5 mm in diameter.

Treatment ID:

TR002300

Treatment Summary:

The control group (N, normal tissue, n=7) comprised animals that did not develop lesions or tumors (C57BL/6 wt mice); the pancreatitis group (Pt, n=6) comprised C57BL/6 wt mice in which acute pancreatitis was induced by six hourly intraperitoneal 50 ug/kg caerulein (Sigma-Aldrich, Dorset, UK) injections; the low grade lesion group (LG, n=5) comprised 4-month old KC (LSL-KrasG12D/+ - p48Cre/+) mice with predominant LG PanIN lesions (mPanIN 1 and 1A); the high grade lesion group (HG, n=7) comprised 9-month old KC mice with predominant HG PanIN lesions (mPanIN 2 and 3); the spontaneous pancreatic ductal adenocarcinoma (PDA, n=6) and sarcomatoid (Sarc., n=9) groups corresponded to 3-6 month old KPC (LSL-KrasG12/D+;LSL-Tpr53R172H/+;Pdx-1-Cre) mice. Tumors were studied when they were less than 5 mm in diameter.