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MB Sample ID: SA211342
Local Sample ID: | MB-ES-121102-31_PDA |
Subject ID: | SU002288 |
Subject Type: | Mammal |
Subject Species: | Mus musculus |
Taxonomy ID: | 10090 |
Genotype Strain: | C57BL/6 (WT); LSL-KrasG12D/+ - p48Cre/+; LSL-KrasG12/D+; LSL-Tpr53R172H/+; Pdx-1-Cre |
Age Or Age Range: | 1.5 to 9 months |
Animal Light Cycle: | 12h light/dark cycles (7.00 AM lights on) |
Animal Feed: | ad libitum |
Animal Water: | ad libitum |
Animal Inclusion Criteria: | Healthy animails |
Species Group: | C57BL/6 (WT); LSL-KrasG12D/+ - p48Cre/+; LSL-KrasG12/D+; LSL-Tpr53R172H/+; Pdx-1-Cre |
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Treatment:
Treatment ID: | TR002300 |
Treatment Summary: | The control group (N, normal tissue, n=7) comprised animals that did not develop lesions or tumors (C57BL/6 wt mice); the pancreatitis group (Pt, n=6) comprised C57BL/6 wt mice in which acute pancreatitis was induced by six hourly intraperitoneal 50 ug/kg caerulein (Sigma-Aldrich, Dorset, UK) injections; the low grade lesion group (LG, n=5) comprised 4-month old KC (LSL-KrasG12D/+ - p48Cre/+) mice with predominant LG PanIN lesions (mPanIN 1 and 1A); the high grade lesion group (HG, n=7) comprised 9-month old KC mice with predominant HG PanIN lesions (mPanIN 2 and 3); the spontaneous pancreatic ductal adenocarcinoma (PDA, n=6) and sarcomatoid (Sarc., n=9) groups corresponded to 3-6 month old KPC (LSL-KrasG12/D+;LSL-Tpr53R172H/+;Pdx-1-Cre) mice. Tumors were studied when they were less than 5 mm in diameter. |