Metabolomics Workbench : NIH Data Repository

MB Sample ID: SA254197

Local Sample ID:	OC189
Subject ID:	SU002621
Subject Type:	Human
Subject Species:	Homo sapiens
Taxonomy ID:	9606

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Treatment:

Treatment ID:	TR002633
Treatment Summary:	Serum samples were collected from two independent tissue banks in South Korea, Dongsan Hospital Human Tissue Bank and Gangnam Severance Hospital Gene Bank. The Severance cohort included 185 samples from ovarian cancer patients, 47 from women with benign ovarian tumor, 50 from invasive cervical cancer and 21 samples from patients with benign uterine tumor. Blood was collected from all patients during surgery after anesthesia and at least 8 hours of fasting. In the Dongsan cohort 88 women had ovarian cancer, 12 had benign ovarian tumor, 10 had benign uterine tumor, and 9 women had cervical cancer. As with the Severance cohort, samples from these patients were collected during surgery after anesthesia and at least 6 hours of fasting. All recruited participants were of Korean descent. Samples from both cohorts were grouped together and patients with ovarian cancer (OC) and all other gynecological malignancies (non-OC) were age matched. The matched cohort included 208 patients with ovarian cancer (mean age 51.9 years) and 137 non-OC patients (mean age 49.9 years). Among the OC patients, 93 patients had early stage (I and II) cancer. Ten of the OC patients had recurrent cancer and 9 patients have had their samples collected more than once. In addition to diseased patients, samples from normal controls (women with no known gynecological malignancies) were collected during regular health exams at Severance hospital. In this case, blood was collected at least 8 hours after fasting. As noted earlier, blood from diseased patients was collected after the initiation of anesthesia, and thus could not be directly compared with normal controls without introducing major confounding effects. Therefore, control samples were excluded from our main analysis. However, for information purposes only, we also provide a lipidome comparison between healthy controls and OC patients in supplemental information.

Treatment ID:

TR002633

Treatment Summary:

Serum samples were collected from two independent tissue banks in South Korea, Dongsan Hospital Human Tissue Bank and Gangnam Severance Hospital Gene Bank. The Severance cohort included 185 samples from ovarian cancer patients, 47 from women with benign ovarian tumor, 50 from invasive cervical cancer and 21 samples from patients with benign uterine tumor. Blood was collected from all patients during surgery after anesthesia and at least 8 hours of fasting. In the Dongsan cohort 88 women had ovarian cancer, 12 had benign ovarian tumor, 10 had benign uterine tumor, and 9 women had cervical cancer. As with the Severance cohort, samples from these patients were collected during surgery after anesthesia and at least 6 hours of fasting. All recruited participants were of Korean descent. Samples from both cohorts were grouped together and patients with ovarian cancer (OC) and all other gynecological malignancies (non-OC) were age matched. The matched cohort included 208 patients with ovarian cancer (mean age 51.9 years) and 137 non-OC patients (mean age 49.9 years). Among the OC patients, 93 patients had early stage (I and II) cancer. Ten of the OC patients had recurrent cancer and 9 patients have had their samples collected more than once. In addition to diseased patients, samples from normal controls (women with no known gynecological malignancies) were collected during regular health exams at Severance hospital. In this case, blood was collected at least 8 hours after fasting. As noted earlier, blood from diseased patients was collected after the initiation of anesthesia, and thus could not be directly compared with normal controls without introducing major confounding effects. Therefore, control samples were excluded from our main analysis. However, for information purposes only, we also provide a lipidome comparison between healthy controls and OC patients in supplemental information.