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MB Sample ID: SA346797
Local Sample ID: | DS2-039-030 |
Subject ID: | SU003304 |
Subject Type: | Mammal |
Subject Species: | Mus musculus |
Gender: | Not applicable |
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Treatment:
Treatment ID: | TR003313 |
Treatment Summary: | All animal procedures were carried out in accordance with the IACUC-approved protocol of Cincinnati Children’s Hospital Medical Center. Animals were monitored daily by Veterinary Services. For subcutaneous tumor implantation, 1x10^6 B16F10 cells were mixed with matrigel 1:1 and implanted subcutaneously into NOD-SCID IL2Rgnull or C57BL/6 mice, respectively. CAY10566 was suspended in 0.5% Methyl Cellulose in water with 0.2% Tween 80 at 9 parts per 1 part DMSO stock. CAY10566 was administered at 30mg/kg via oral gavage, twice daily, with a drug holiday during the weekends. Treatment began three days after tumor cell implantation (bilateral tumors in n=4 per group). Mice were euthanized17 days after tumor cell injection/14 days after the start of treatment. |