Summary of Study ST001041
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000697. The data can be accessed directly via it's Project DOI: 10.21228/M8KH4V This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST001041 |
Study Title | Development of a weaned pig model of enterotoxigenic E.coli-induced environmental enteropathy |
Study Type | Animal Model |
Study Summary | Environmental Enteropathy (EE) is a subclinical condition primarily effecting developing countries believed to be caused by chronic fecal-oral contamination. The condition is characterized by chronic gut inflammation, malabsorption, stunting of growth, stunted villi, and reduced efficacy of oral vaccines. Due to the similarity of the gastrointestinal tract and immune response of swine and humans, the piglet is an attractive model for studying this condition. In this present study, piglets were challenged with either a chronic or acute dose of pathogenic E.coli in an attempt to mimic the symptoms of EE over a 7 day trial period. Throughout the study a number of biological samples were collected for analysis and are presented here, including feces for untargeted metabolomics analysis. |
Institute | Texas A&M University |
Department | Animal Science |
Laboratory | Gill Lab |
Last Name | Boeckman |
First Name | Justin |
Address | 400 Bizzell Street |
Jxboeckman@tamu.edu | |
Phone | 4084893729 |
Submit Date | 2018-08-21 |
Num Groups | 3 |
Total Subjects | 24 |
Publications | In progress |
Analysis Type Detail | GC-MS |
Release Date | 2018-10-10 |
Release Version | 1 |
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Treatment:
Treatment ID: | TR001096 |
Treatment Summary: | 24 Piglets were blocked into 3 different treatment groups. Acute treatment received a one time oral dose of 6mls of 10^9 CFU/ml of overnight shiga toxigenic E.coli culture. Chronic treatment received a 6ml daily dose of 1/10th dilution of overnight culture at 10^8 CFU/ml. The control group received a sham dose of PBS. At the conclusion of the trial on Day 7 piglets were euthanized and necropsied. |
Treatment Compound: | Pathogenic Shigatoxigenic E.coli (ATCC 23545) |
Treatment Dose: | One time vs Daily Dose |
Treatment Dosevolume: | 6ml of 10^9 CFU/ml, 10^8 CFU/ml, or PBS |
Treatment Vehicle: | Oral Gavage |