Summary of Study ST001652
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001058. The data can be accessed directly via it's Project DOI: 10.21228/M8XX2B This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST001652 |
Study Title | Atypical Molecular Basis for Drug Resistance to Mitochondrial AQ: A Function Inhibitors in Plasmodium falciparum |
Study Summary | In this study, we present a clear genotype for the P. falciparum SB1-A6 acridone-resistant clonal parasite strain and, through a combination of targeted and whole-cell methods, establish that the mechanism of resistance to both cytochrome bc1 and DHODH inhibitors results from the contribution of multiple genetic polymorphisms. We find that P. falciparum SB1-A6 accumulates both a copy number variation and a specific mutation in PfDHODH, and both of these genetic polymorphisms contribute to the panresistant phenotype. This study uncovers a mechanism of cross-resistance between PfDHODH and mtETC inhibitors and serves as a cautionary note to future antimalarial combination therapy formulations containing such drugs. |
Institute | U.S. Food & Drug Administration |
Last Name | Painter |
First Name | Heather |
Address | 10903 New Hampshire Ave., WO 52/72-5324, Silver Spring, MD 20993 |
Heather.Painter@fda.hhs.gov | |
Phone | 240-402-2040 |
Submit Date | 2021-01-17 |
Publications | DOI:10.1128/AAC.02143-20 |
Raw Data Available | Yes |
Raw Data File Type(s) | mzXML |
Analysis Type Detail | LC-MS |
Release Date | 2021-02-01 |
Release Version | 1 |
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Treatment:
Treatment ID: | TR001742 |
Treatment Summary: | Trophozoite-stage Plasmodium infected RBCs were treated with 10x IC50 of either drug for 2.5 hours |