Summary of Study ST002769
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001726. The data can be accessed directly via it's Project DOI: 10.21228/M8M70W This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002769 |
| Study Title | The ECHO Cohort Exposome: First Steps using HHEAR Analysis – An Opportunity for ALL ECHO Cohorts to Contribute Type A Samples – Untargeted Analysis (INSPIRE Cohort) |
| Study Type | Prospective Birth Cohort Study |
| Study Summary | The INSPIRE (Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure Study) is a population-based birth cohort of 1952 term healthy infants who will be followed to at least 11 years of age. The INSPIRE cohort was established under NIAID U19 funding in 2012 and is one of the larger ECHO cohorts. The cohort was designed such that infants were born June through December and were, on average, 6 months of age or less during their first RSV season. Biweekly surveillance was done November through April of the first year of life, with in-person respiratory illness visits conducted for those who met criteria. Viral pathogens were identified by PCR, and RSV serology was done at one year. Children are followed annually, in some years by survey, and in some years by in-person visits which include skin prick testing to aeroallergens, spirometry with test of reversibility and FeNO. Intermediate outcomes include infant respiratory morbidity, recurrent wheezing, and atopy. Asthma is defined annually using standardized questionnaires. This research was supported by the Environmental influences on Child Health Outcomes (ECHO) Program, Office of The Director, National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. INSPIRE is an ECHO cohort which is supported by the following ECHO Program Collaborators: ECHO Coordinating Center: Duke Clinical Research Institute, Durham, North Carolina: Smith PB, Newby KL, Benjamin DK; U2C OD023375 ECHO Data Analysis Center: Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland: Jacobson LP; Research Triangle Institute, Durham, North Carolina: Catellier D; U24 OD023382 North Carolina Human Health Exposure Analysis Resource Hub: Research Triangle Institute: Fennell T, University of North Carolina at Chapel Hill: Sumner S, University of North Carolina at Charlotte: Du X; U2C ES030857 Human Health Exposure Analysis Resource Coordinating Center: Westat, Inc., Rockville, Maryland: O’Brien B; U24 ES026539 |
| Institute | Vanderbilt University Medical Center |
| Department | Vanderbilt University Medical Center, Department of Medicine, Department of Pediatrics |
| Last Name | Hartert |
| First Name | Tina |
| Address | Center for Asthma Research 2525 West End Ave, Suite 450 Nashville, TN 37203 |
| tina.hartert@vumc.org | |
| Phone | 615-936-1010 / 615-343-3486 (direct office) |
| Submit Date | 2023-06-29 |
| Total Subjects | 630 |
| Study Comments | HHEAR Project EM20-0011, ECHO Project EC0376 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | raw(Thermo) |
| Chear Study | Yes |
| Analysis Type Detail | LC-MS |
| Release Date | 2024-07-01 |
| Release Version | 1 |
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Treatment:
| Treatment ID: | TR002885 |
| Treatment Summary: | N/A |
