Summary of Study ST002851
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001785. The data can be accessed directly via it's Project DOI: 10.21228/M8043D This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002851 |
| Study Title | Metabolic caracterization of liver metastasis organotropism |
| Study Summary | Transcriptomic and metabolomic analyses in animals revealed distinct metabolic adaptations, particularly related to the TCA cycle and OxPhos, specific to liver metastases compared to concurrent lung metastases. This finding was substantiated by analyzing RNA-seq data from a considerable number of patient metastases across various cancer types. Further analysis of exome/RNA-seq data from melanoma patients indicated more frequent PIK3CA mutations, lower transcript levels of PIP4K2C, and enrichment of TCA cycle and OxPhos pathways in liver metastases. |
| Institute | Columbia University |
| Department | Department of Medicine |
| Laboratory | Division of Hematology/Oncology |
| Last Name | Izar |
| First Name | Benjamin |
| Address | Columbia University Irving Medical Center, New York, NY, USA |
| bi2175@cumc.columbia.edu | |
| Phone | 0123456789 |
| Submit Date | 2023-08-31 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | raw(Thermo) |
| Analysis Type Detail | LC-MS |
| Release Date | 2023-10-02 |
| Release Version | 1 |
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Treatment:
| Treatment ID: | TR002972 |
| Treatment Summary: | Briefly, 6-8-week-old female NOD/SCID/IL2gR mice (005557 Jackson Laboratory) were injected via tail vein with 1 x 10^5 A375 human melanoma cell line of indicated genotypes, n=5/group. |
| Animal Endp Euthanasia: | When mice showed signs of sickness, 20% of weight loss, impaired activity, hunching and limb paralysis. |
