Summary of project PR000046
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000046. The data can be accessed directly via it's Project DOI: 10.21228/M84S36 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR000046 |
| Project DOI: | doi: 10.21228/M84S36 |
| Project Title: | Metabolomic & lipidomic profiles in response to exogenous insulin & GLP-1 infusions during prolonged fasting |
| Project Type: | Timecourse |
| Project Summary: | This application requests funding to access state-of-the-art metabolomics and lipidomic platforms at the NIH West Coast Metabolomics Center to analyze plasma samples from recent insulin and glucagon-like peptide-1 (GLP-1) infusion experiments performed in prolong-fasted elephant seals. This suite of studies was designed to better assess the mechanisms contributing to the onset of an insulin resistantlike condition induced by prolonged food deprivation/starvation in mammals. Because elephant seals have evolved robust physiological mechanisms that have allowed them to naturally tolerate such protracted bouts of fasting, they provide an ideal model to address our central hypothesis that increased lipid utilization late in the fast contributes to insulin resistance in elephant seals. Insulin resistance is a common consequence of fasting in mammals and, while the mechanisms by which it manifests are still unclear, a metabolic shift favoring increased mobilization and utilization of lipids during prolonged food deprivation may be a principal causative factor. Insulin resistance has a negative connotation due to its association with obesity and diabetes among humans, but it has been suggested to be an adaptive response to food deprivation. |
| Institute: | University of California, Merced |
| Department: | School of Natural Sciences |
| Laboratory: | Molecular and Cellular Biology, Natural Sciences |
| Last Name: | Ortiz |
| First Name: | Rudy |
| Address: | 5200 N. Lake Rd.; Merced, CA 95343 |
| Email: | rortiz@ucmerced.edu |
| Phone: | 209.228.2964 |
Summary of all studies in project PR000046
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST000048 | Metabolomic & lipidomic profiles in response to exogenous insulin & GLP-1 infusions during prolonged fasting (GCMS) | Mirounga angustirostris | University of California, Davis | MS | 2014-04-24 | 1 | 117 | Uploaded data (2.1G)* |
| ST000107 | Metabolomic and lipidomic profiles in response to exogenous insulin and GLP-1 infusions during prolonged fasting | Mirounga angustirostris | University of California, Davis | MS | 2015-02-03 | 1 | 111 | Uploaded data (751.2M)* |
