Summary of project PR000066
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000066. The data can be accessed directly via it's Project DOI: 10.21228/M8QG6H This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR000066 |
| Project DOI: | doi: 10.21228/M8QG6H |
| Project Title: | Metabolomic profiling of influenza: a 2009 pandemic H1N1 influenza in lean and obese mice |
| Project Type: | Effects and role of obesity on the severity of influenza |
| Project Summary: | During the 2009 H1N1 influenza pandemic outbreak, obese individuals were reported to be at greater risk for morbidity and mortality from pandemic infection. However, the mechanisms contributing to greater influenza severity in infected obese individuals remain unclear. Given that one in ten individuals is obese, and worldwide influenza outbreaks are a consistent public health burden, garnering a better understanding of the pathways and mechanisms contributing to greater influenza severity in the obese is essential for limiting influenza infection mortality in this at-risk population. Closely paralleling pH1N1 infection outcome in humans, obese mice exhibit increased morbidity and mortality following pH1N1 infection. In mice, obesity impairs the function of natural killer cells, dendritic cells, macrophage, B cells and memory T cells. Further, several analyses of lung antiviral responses revealed that obese mice have greater lung damage, lung immune cell infiltration and impaired lung healing after infection. Nevertheless, it remains unclear how altered immune cell function contributes to greater lung damage and increased infection severity in obese mice. Metabolomics will be used to dissect the metabolic consequences of obesity on the immune response to pH1N1 infection. We will compare metabolic profiles of lung-specific and peripheral samples from uninfected and infected lean and obese mice during early and late phases of influenza immunity. |
| Institute: | University of North Carolina at Chapel Hill |
| Department: | Department of Nutrition |
| Last Name: | Beck |
| First Name: | Melinda |
| Address: | 2303 MHRB, CB #7461, UNC, Chapel Hill NC 27599 |
| Email: | melinda_beck@unc.edu |
| Phone: | 919-966-6809 |
Summary of all studies in project PR000066
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST000069 | Metabolomic profiling of influenza: a 2009 pandemic H1N1 influenza in lean and obese mice (via blood and tissue) | Mus musculus | University of North Carolina | MS | 2015-06-01 | 1 | 70 | Uploaded data (6.3M) |
| ST000070 | Metabolomic profiling of influenza: a 2009 pandemic H1N1 influenza in lean and obese mice (via tissue) | Mus musculus | University of North Carolina | MS | 2015-07-01 | 1 | 37 | Uploaded data (5.7M) |
| ST000071 | Metabolomic profiling of influenza: a 2009 pandemic H1N1 influenza in lean and obese mice (via Urine) | Mus musculus | University of North Carolina | MS | 2015-07-31 | 1 | 25 | Uploaded data (3.1M) |
