Summary of project PR000087

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000087. The data can be accessed directly via it's Project DOI: 10.21228/M8F30Z This work is supported by NIH grant, U2C- DK119886.


Project ID: PR000087
Project DOI:doi: 10.21228/M8F30Z
Project Title:Dysfunctional lipid metabolism underlies the effect of perinatal DDT exposure on the development of metabolic syndrome
Project Type:Animal chemical exposure and feeding study
Project Summary:This study evaluated the effect of perinatal DDT exposure on metabolic syndrome in mice exposed to doses that mimicked human exposure. The samples tested were from 2 groups: 1) a group with perinatal exposure to DDT consuming a high fat diet (DDHF), 2) a control group consuming a high fat diet (CHF). Results indicated the DDHF group had comparatively elevated plasma concentrations of glucose, insulin, cholesterol, and triglycerides, CYP7A1 gene expression, homeostasis model assessment- insulin resistance (HOMA-IR), and fat mass (%), as well as reduced thermogenesis. These data suggest perinatal DDT exposure may cause the co-occurrence of conditions associated with metabolic syndrome, including glucose intolerance, hyperinsulinemia, and dyslipidemia, impaired thermogenesis, and obesity.
Institute:University of California, Davis
Department:Environmental Toxicology
Laboratory:La Merrill
Last Name:La Merrill
First Name:Michele
Address:1 Shields Ave, Davis CA
Funding Source:National Institute of Health (R00 ES019919, R03 DK082724, U24 DK092993, U24 DK097154, T32 ES007059, and P60 DK020541), the American Diabetes Association, and USDA-ARS intramural Project 5306-51530-019-00D

Summary of all studies in project PR000087

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST000095 Dysfunctional lipid metabolism underlies the effect of perinatal DDT exposure on the development of metabolic syndrome Mus musculus University of California, Davis MS 2015-02-03 1 15 Uploaded data (22.1M)*