Summary of project PR000087
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000087. The data can be accessed directly via it's Project DOI: 10.21228/M8F30Z This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR000087 |
| Project DOI: | doi: 10.21228/M8F30Z |
| Project Title: | Dysfunctional lipid metabolism underlies the effect of perinatal DDT exposure on the development of metabolic syndrome |
| Project Type: | Animal chemical exposure and feeding study |
| Project Summary: | This study evaluated the effect of perinatal DDT exposure on metabolic syndrome in mice exposed to doses that mimicked human exposure. The samples tested were from 2 groups: 1) a group with perinatal exposure to DDT consuming a high fat diet (DDHF), 2) a control group consuming a high fat diet (CHF). Results indicated the DDHF group had comparatively elevated plasma concentrations of glucose, insulin, cholesterol, and triglycerides, CYP7A1 gene expression, homeostasis model assessment- insulin resistance (HOMA-IR), and fat mass (%), as well as reduced thermogenesis. These data suggest perinatal DDT exposure may cause the co-occurrence of conditions associated with metabolic syndrome, including glucose intolerance, hyperinsulinemia, and dyslipidemia, impaired thermogenesis, and obesity. |
| Institute: | University of California, Davis |
| Department: | Environmental Toxicology |
| Laboratory: | La Merrill |
| Last Name: | La Merrill |
| First Name: | Michele |
| Address: | 1 Shields Ave, Davis CA |
| Email: | mlamerrill@ucdavis.edu |
| Phone: | +1-530-754-7254 |
| Funding Source: | National Institute of Health (R00 ES019919, R03 DK082724, U24 DK092993, U24 DK097154, T32 ES007059, and P60 DK020541), the American Diabetes Association, and USDA-ARS intramural Project 5306-51530-019-00D |
Summary of all studies in project PR000087
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST000095 | Dysfunctional lipid metabolism underlies the effect of perinatal DDT exposure on the development of metabolic syndrome | Mus musculus | University of California, Davis | MS | 2015-02-03 | 1 | 15 | Uploaded data (22.1M)* |
