Summary of project PR000200
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000200. The data can be accessed directly via it's Project DOI: 10.21228/M8JC79 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR000200 |
| Project DOI: | doi: 10.21228/M8JC79 |
| Project Title: | Metabolic heterogeneity in Glioblastoma |
| Project Summary: | Glioblastoma (GB) is the most common and complex primary brain tumor in adults and has a dismal prognosis, which is attributed largely to the extreme heterogeneity in the cells that make up the cancer and the continual molecular, genetic and metabolic adaptations driving tumor initiation, propagation and resistance to conventional treatments. The most important clinical target to prevent these mechanisms of initiation, propagation and disease recurrence may be a subset of tumor cells, cancer stem cells. Hence, identifying targetable key features of this population is of great interest for the elaboration of strategies to prevent disease initiation and propagation as well as recurrence post treatments. In response to i) the limited success to treat GB that remains universally fatal, ii) the evidences pointing to tumor heterogeneity as the greatest obstacle to achieve therapeutic efficacy and iii) the increasing understanding and importance of bioenergetics in tumor biology and the critical need to integrate metabolism into treatment paradigms, we propose a new model residing in the unique and unprecedented hypothesis of an association between GB management, a distinct slow-cycling cancer stem cell subpopulation and metabolic targeting. |
| Institute: | University of Florida |
| Department: | McKnight Brain Institute, Neurosurgery |
| Last Name: | Deleyrolle |
| First Name: | Loic |
| Address: | #N/A |
| Email: | l.deleyrolle@gmail.com |
| Phone: | 352-682-1961 |
Summary of all studies in project PR000200
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST000248 | Metabolic heterogeneity in Glioblastoma | Homo sapiens | University of Florida | MS | 2016-09-23 | 1 | 6 | Uploaded data (733.6M)* |
