Summary of project PR000206
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000206. The data can be accessed directly via it's Project DOI: 10.21228/M8RW2F This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR000206 |
| Project DOI: | doi: 10.21228/M8RW2F |
| Project Title: | The role of microbial metabolites in experimental liver disease |
| Project Type: | Targeted Metabolomics |
| Project Summary: | Liver fibrosis is the result of chronic liver damage from various etiologies including toxins, alcohol abuse, obesity, or viral hepatitis. Chronic liver disease may progress to cirrhosis, an end stage organ disease, and liver cancer. Patients with chronic liver disease show intestinal bacterial overgrowth and dysbiosis. They also demonstrate increased intestinal permeability, and disease severity correlates with systemic levels of bacterial products. Although experimental liver fibrosis is dependent on gut derived bacterial products, the exact contribution of the commensal microflora to chronic liver disease in unknown. Since the interaction of bacterial products with the innate immune system can also confer protection to the host, we subjected germfree mice to experimental models of liver fibrosis. Results from our laboratory demonstrate that germfree mice show exacerbated liver fibrosis as compared to conventional mice. Our previous studies also have indicated that a bacterial metabolite of tryptophan, Indole-3-propionic Acid (IPA), is absent in germ free mice. In this study we are investigating the role of IPA in acute and chronic models of liver fibrosis. |
| Institute: | University of California, San Diego |
| Last Name: | Schnabl |
| First Name: | Bernd |
| Address: | 9500 Gilman Drive, MC0063 La Jolla, CA 92093 |
| Email: | beschnabl@ucsd.edu |
| Phone: | 858-822-5311 |
Summary of all studies in project PR000206
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST000254 | The role of microbial metabolites in experimental liver disease | Mus musculus | University of North Carolina | MS | 2016-12-22 | 1 | 48 | Uploaded data (1.3M)* |
