Summary of project PR000245

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000245. The data can be accessed directly via it's Project DOI: 10.21228/M8401H This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Project ID: PR000245
Project DOI:doi: 10.21228/M8401H
Project Title:Pig Athersclerosis Model
Project Summary:Insulin-resistant subjects develop more severe and diffuse coronary artery atherosclerosis than insulin sensitive control but the mechanisms that mediate the atherosclerosis phenotype are unknown. The objective of this study is to investigate whether the severity of atherosclerosis is associated not only with lipoprotein concentrations, weight, blood pressure, biomarkers of inflammation and IR in an animal model but also changes in parameters that measure protein glycation. The experimental approach was to study normocholestrolemic pigs fed a high fat diet that also contained increased NaCl. The choice of pigs was driven by the fact that, like humans, they develop coronary artery and aortic atherosclerosis and insulin resistance. In addition, pigs have been used in many studies to define the mechanisms that mediate increased atherosclerosis in diabetes.
Institute:University of North Carolina at Chapel Hill
Department:Department of Pathology and Laboratory Medicine
Last Name:Nichols
First Name:Timothy
Address:-
Email:tnichols@med.unc.edu
Phone:-

Summary of all studies in project PR000245

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)		 Release
Date		VersionSamplesDownload
(* : Contains raw data)
ST000305 Pig Athersclerosis Model Sus scrofa University of North Carolina NMR 2016-12-31 1 90 Uploaded data (49.2M)*
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