Summary of project PR000253
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000253. The data can be accessed directly via it's Project DOI: 10.21228/M8302K This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR000253 |
| Project DOI: | doi: 10.21228/M8302K |
| Project Title: | NSAID treatment alters the metabolomics profile of liver, kidney, lung, and heart in an experimental mouse model of heat stroke |
| Project Summary: | Heat stroke (HS) is a significant medical threat to civilians and those serving in the U.S. Armed forces. The physiological and molecular mechanisms that are critical in HS morbidity and mortality, both during and after HS onset, remain yet to be elucidated. Current clinical biomarkers lack specificity and sensitivity to accurately diagnose HS severity, and there is a critical need for effective pharmacologic interventions and treatments that address this life-threatening disease. The systemic inflammatory response (SIR) is one target for such pharmacological interventions, as it is thought to mediate much of HS etiology. For this reason, anti-inflammatories have been directed at the SIR in an effort to treat and prevent HS. Due to their anti-inflammatory actions, non-steroidal anti-inflammatory drugs (NSAIDS) have been suggested as a treatment candidate for HS. Currently, NSAIDs are one of the most widely used medications across the world, with hundreds of millions of doses prescribed yearly. Of special concern, NSAID use is prolific throughout the U.S. Armed Forces. We recently examin4ed the effect of using NSAIDs to treat HS, and found that NSAIDs actually increase HS mortality and exacerbate the systemic organ damage (e.g., gut, kidneys) found in HS recovery in mice. Our finding suggest the use of NSAIDs by civilians and military populations may increase the risk of HS morbidity and mortality. The objective of this proposal is to exploit broad spectrum metabolomic analysis to identify new biomarkers of multi-organ damage that will improve HS diagnosis and treatment. |
| Institute: | US Army Research Institute |
| Department: | Environmental Medicine |
| Last Name: | Audet;Leon |
| First Name: | Gerald;Lisa |
| Address: | Building 42, Kansas Street, Natick, MA 01760 |
| Email: | gerald.n.audet.ctr@mail.mil |
| Phone: | 508.233.5959 |
Summary of all studies in project PR000253
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST000314 | NSAID treatment alters the metabolomics profile of liver, kidney, lung, and heart in an experimental mouse model of heat stroke | Mus musculus | University of North Carolina | NMR | 2016-12-31 | 1 | 92 | Uploaded data (49.8M)* |
