Summary of project PR000290
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000290. The data can be accessed directly via it's Project DOI: 10.21228/M8JW2K This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR000290 |
| Project DOI: | doi: 10.21228/M8JW2K |
| Project Title: | Zebrafish Metabolomics: Model for Environmental Metal Toxicity |
| Project Summary: | This metabolomics seed project will test the hypothesis that zebrafish can provide mechanistic insights into the human health effects of developmental exposure to Cd and Pb. We will use broad spectrum metabolomics of zebrafish larvae after exposure to Cd, Pb, and Cd and Pb compared to controls. Activity observed at 5 days post fertilization is will be used to determine if there is a correlation between biological pathways implicated by these metabolic profiles and cardiovascular, metabolic (obesity), and neurological phenotypes. The behavioral phenotypes have been quantified in zebrafish previously and have been measured in the Newborn Epigenetic STudy (NEST), a NIH-funded project that is investigating how environmental exposures and nutrition, in the womb and during childhood, affect how genes work and how these exposures developed into obesity and other diseases, disorders, and conditions. The results from this study will demonstrate the power of using zebrafish as a model for mechanism discovery in exposure using metabolomics to advance understanding of early life exposure to Cd and Pb and serve as preliminary data for opportunities. |
| Institute: | North Carolina State University |
| Last Name: | Mattingly |
| First Name: | Carolyn |
| Address: | 142 David Clark Labs, Raleigh, NC 27695-7617 |
| Email: | cjmattin@ncsu.edu |
| Phone: | 919-515-2024 |
Summary of all studies in project PR000290
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST000365 | Zebrafish Metabolomics: Model for Environmental Metal Toxicity | Danio rerio | University of North Carolina | NMR | 2017-10-03 | 1 | 45 | Uploaded data (22.6M)* |
