Summary of project PR000320
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000320. The data can be accessed directly via it's Project DOI: 10.21228/M8MP4W This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR000320 |
| Project DOI: | doi: 10.21228/M8MP4W |
| Project Title: | Metabolomic analysis of oxytocin effects on social deficits in mice |
| Project Summary: | The goal of this study was to determine the effects of the neuropeptide oxytocin (OT) on metabolomic profiles, using a mouse model of autism-like behavior, the BALB/cByJ inbred strain. We have previously reported that subchronic treatment with OT can lead to persistent reversal of social deficits in BALB/cByJ and other models of autism spectrum disorder (ASD). In this study, mice were given a subchronic regimen with either vehicle or OT, and then evaluated for social approach. At the end of the study, brain and blood were collected for metabolomic analysis. In addition, fecal samples were taken at different time points during the treatment and testing regimen. The results from this project could elucidate mechanisms underlying the prosocial effects of oxytocin, and identify new targets for the development of highly specific oxytocin-related drugs. |
| Institute: | University of North Carolina at Chapel Hill |
| Department: | Department of Psychiatry |
| Last Name: | Moy |
| First Name: | Sheryl |
| Address: | CB# 7146, Chapel Hill, NC 277599 |
| Email: | ssmoy@med.unc.edu |
| Phone: | 919-966-3082 |
Summary of all studies in project PR000320
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST000408 | Metabolomic analysis of oxytocin effects on social deficits in mice (part I) | Mus musculus | University of North Carolina | NMR | 2018-06-05 | 1 | 104 | Uploaded data (55.2M)* |
| ST000409 | Metabolomic analysis of oxytocin effects on social deficits in mice (part II) | Mus musculus | University of North Carolina | NMR | 2018-06-05 | 1 | 85 | Uploaded data (44M)* |
| ST000410 | Metabolomic analysis of oxytocin effects on social deficits in mice (part III) | Mus musculus | University of North Carolina | NMR | 2017-07-10 | 1 | 103 | Uploaded data (100.2M)* |
| ST000476 | Metabolomic analysis of oxytocin effects on social deficits in mice (part IV) | Mus musculus | University of North Carolina | MS* | 2017-10-03 | 1 | 22 | Uploaded data (1.1G)* |
