Summary of project PR000340
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000340. The data can be accessed directly via it's Project DOI: 10.21228/M85G6J This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR000340 |
| Project DOI: | doi: 10.21228/M85G6J |
| Project Title: | Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways |
| Project Summary: | Here we interrogated the in vitro metabolic effects of 189 drugs (including 169 of the drug-like compounds from the Malaria Box) using ultra-high performance liquid chromatography mass-spectrometry (UHPLC-MS). The resulting metabolic fingerprints provide information on the parasite biochemical pathways affected by pharmacologic intervention and offer a critical blueprint for selecting and advancing lead compounds as next-generation antimalarial drugs. Our results reveal several major classes of metabolic disruption, which allow us to predict the mode-of-action (MoA) for many of the Malaria Box compounds. |
| Institute: | Pennsylvania State University |
| Last Name: | Llinás |
| First Name: | Manuel |
| Address: | W126 Millenium Science Complex, University Park, PA 16802 |
| Email: | manuel@psu.edu |
| Phone: | (814) 867-3527 |
Summary of all studies in project PR000340
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST000441 | Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways | Plasmodium falciparum | Pennsylvania State University | MS | 2016-12-22 | 1 | 189 | Uploaded data (553.8K) |
