Summary of project PR000389
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000389. The data can be accessed directly via it's Project DOI: 10.21228/M8S02S This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR000389 |
| Project DOI: | doi: 10.21228/M8S02S |
| Project Title: | Effects of herb DG and KK01 on Type 2 Diabetes Mellitus (T2DM) |
| Project Type: | LC-MS Lipidomics |
| Project Summary: | The long-term goal of this research is to use a system pharmacology approach to investigate novel drugs for type 2 diabetes based on the experience of Traditional Chinese Medicine (TCM). The aim of the current study is to use lipidomics to evaluate the anti-diabetic efficacy of DG extract and its major compounds and to interpret the drug targets and mechanisms. DG is a typical “heat clearing” herb in TCM, and has long been used as a treatment for type 2 diabetes. Phytochemicals with KK structure are the predominant constituents in DG extract, and KK01 is the major form, with a content of around 2% of dry herb. To verify that KK01 is the bioactive compound responsible for the effect of DG, we designed an animal experiment to investigate the efficacies of DG and KK01 on db/db mice in comparison to two first-line anti-diabetic drugs, metformin and rosiglitazone. It was found that after 9 weeks of treatments, KK01 was effective in inhibiting the increase of blood glucose of db/db mice, with effects comparable to metformin and rosiglitazone. To understand the mechanism, the mice blood was collected in fasting status, and the serum was separated and divided into three aliquots for lipidomics, cytokine array and Biocrates analysis. This study will focus on lipidomics analysis. |
| Institute: | RTI International |
| Department: | Systems and Translational Sciences |
| Laboratory: | RTI Eastern Regional Comprehensive Metabolomics Resource Core (RTI ERCMRC) |
| Last Name: | Li |
| First Name: | Yuanyuan |
| Address: | 3040 East Cornwallis Road, Research Triangle Park, NC 27709, USA |
| Email: | yli@rti.org |
| Phone: | 9199908327 |
Summary of all studies in project PR000389
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST000530 | Effects of herb DG and KK01 on Type 2 Diabetes Mellitus (T2DM) through Lipidomics | Mus musculus | University of North Carolina | MS* | 2018-02-07 | 1 | 93 | Uploaded data (7.7G)* |
