Summary of project PR000410
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000410. The data can be accessed directly via it's Project DOI: 10.21228/M82889 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR000410 |
| Project DOI: | doi: 10.21228/M82889 |
| Project Title: | Urine metabolomic profiling of diabetic nephropathy in the steptozotocin induced type-1 diabetes mouse model. |
| Project Summary: | Diabetic nephropathy (DN) is the leading cause of end stage renal disease, and is associated with high morbidity and mortality rates. The pathophysiology of DN includes both glomerular and tubulointerstitial damage. Meprins are metalloproteinases which are most abundantly expressed in the brush border membranes of proximal kidney tubules. Meprins are also expressed in leukocytes (monocytes and macrophages) and podocytes. Meprins have been implicated in the pathology of acute and chronic kidney injury. Single nucleotide polymorphisms (SNPs) in the meprin β gene were associated in human DN in the Pima Indians, suggesting a role for meprins in the pathophysiology of DN. The current study was done to determine the mechanisms by which meprins modulate the progression of DN in mice. |
| Institute: | North Carolina A&T State University |
| Department: | Department of Biology |
| Last Name: | Ongeri |
| First Name: | Elimelda Moige |
| Address: | 1601 E Market Street, Greensboro, NC 27411 |
| Email: | eongeri@ncat.edu |
| Phone: | 336-285-2182 |
| Funding Source: | NIH/NIGMS Grant # SC3102049 To Elimelda Moige Ongeri; NIH Center Grant # U24DK097193 to Susan Sumner; NIH/NCATS award # UL1TR001111 to John Buse, UNC-CH, PI, Sumner- Director, Metabolomics core; and NIH/NIGMS Grant # K01GM109320 to Jessica Gooding. |
Summary of all studies in project PR000410
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST000559 | Urine metabolomic profiling of diabetic nephropathy in the steptozotocin induced type-1 diabetes mouse model. | Mus musculus | RTI International | MS* | 2018-04-10 | 1 | 54 | Uploaded data (72.6G)* |
