Summary of project PR000457
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000457. The data can be accessed directly via it's Project DOI: 10.21228/M8060Z This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR000457 |
| Project DOI: | doi: 10.21228/M8060Z |
| Project Title: | Metabolomic Mechanisms of Dietary Salt Effects on Blood Pressure |
| Project Summary: | Enhanced sensitivity of blood pressure to salt intake is observed in approximately 50% of hypertensive patients, reaching 75% in African American hypertensive patients. We recently discovered a novel role of abnormal cellular intermediary metabolism in hypertension in the Dahl salt-sensitive (SS) rat, the most commonly used polygenic, hereditary model of human salt-sensitive hypertension. We propose to test the hypothesis that blood pressure sensitivity to dietary salt intake in human is associated with metabolite changes in the urine. Leveraging the expertise and resources at the Mayo Clinic Metabolomics Resources Core, we propose to perform targeted LC/MS analysis and NMR spectra generation in urine samples obtained from a subset of subjects from the Dietary Approaches to Stop Hypertension – Sodium (DASH2) clinical trial and kidney tissue extract and urine samples from SS rats and a newly generated transgenic rat that overexpresses fumarase (SS.Fh1+). The study will be the first to systematically characterize urinary metabolite profiles associated with blood pressure response to salt in humans. The study is anticipated to generate new insight into the mechanisms (particularly renal mechanisms) underlying salt-sensitive hypertension. Findings of the proposed study could lead to an expanded clinical study as well as mechanistic studies in animal models. |
| Institute: | Mayo Clinic |
| Last Name: | Liang |
| First Name: | Mingyu |
| Address: | Medical College of Wisconsin 8701 Watertown Plank Road Milwaukee, WI 53226 |
| Email: | mliang@mcw.edu |
| Phone: | 414-955-8539 |
Summary of all studies in project PR000457
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST000628 | TCA Cycle Metabolites of Dietary Salt Effects on Blood Pressure in Human Urine from 20 Participants of the DASH2 Clinical Trial (part I) | Homo sapiens | Mayo Clinic | MS | 2019-07-17 | 1 | 40 | Not available |
| ST000629 | Amino Acd Metabolites of Dietary Salt Effects on Blood Pressure in Human Urine from 20 Participants of the DASH2 Clinical Trial (part II) | Homo sapiens | Mayo Clinic | MS | 2019-07-17 | 1 | 40 | Not available |
| ST000630 | Neuromodulator Metabolites of Dietary Salt Effects on Blood Pressure in Human Urine from 20 Participants of the DASH2 Clinical Trial (part III) | Homo sapiens | Mayo Clinic | MS | 2019-07-17 | 1 | 40 | Not available |
| ST000631 | TCA Cycle Metabolites of Dietary Salt Effects on Blood Pressure in Rat Urine (part IV) | Rattus norvegicus | Mayo Clinic | MS | 2019-07-17 | 1 | 36 | Not available |
| ST000632 | Amino Acid Metabolites of Dietary Salt Effects on Blood Pressure in Rat Urine (part V) | Rattus norvegicus | Mayo Clinic | MS | 2019-07-17 | 1 | 36 | Not available |
| ST000633 | Neuromodulator Metabolites of Dietary Salt Effects on Blood Pressure in Rat Urine (part VI) | Rattus norvegicus | Mayo Clinic | MS | 2019-07-17 | 1 | 36 | Not available |
| ST000634 | TCA Cycle Metabolites of Dietary Salt Effects on Blood Pressure in Human Urine from DASH2 Clinical Trial (part VII) | Homo sapiens | Mayo Clinic | MS | 2019-07-17 | 1 | 166 | Not available |
| ST000635 | Amino Acid Metabolites of Dietary Salt Effects on Blood Pressure in Human Urine from DASH2 Clinical Trial (part VIII) | Homo sapiens | Mayo Clinic | MS | 2019-07-17 | 1 | 166 | Not available |
| ST000636 | Neuromodulator Metabolites of Dietary Salt Effects on Blood Pressure in Human Urine from DASH2 Clinical Trial (part IX) | Homo sapiens | Mayo Clinic | MS | 2019-07-17 | 1 | 166 | Not available |
| ST000637 | TCA Cycle Metabolites of Dietary Salt Effects on Blood Pressure in Rat Urine and Kidney Tissue (part X) | Rattus norvegicus | Mayo Clinic | MS | 2019-07-17 | 1 | 24 | Not available |
| ST000638 | Amino Acid Metabolites of Dietary Salt Effects on Blood Pressure in Rat Urine and Kidney Tissue (part XI) | Rattus norvegicus | Mayo Clinic | MS | 2019-07-17 | 1 | 24 | Not available |
| ST000639 | Neuromodulator Metabolites of Dietary Salt Effects on Blood Pressure in Rat Urine and Kidney Tissue (part XII) | Rattus norvegicus | Mayo Clinic | MS | 2019-07-17 | 1 | 8 | Not available |
