Summary of project PR000463
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000463. The data can be accessed directly via it's Project DOI: 10.21228/M86P5J This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR000463 |
| Project DOI: | doi: 10.21228/M86P5J |
| Project Title: | Changes in metabolites and lipid mediators associated with supervised exercise training for peripheral artery disease |
| Project Summary: | Peripheral artery disease (PAD) is a leading cause of cardiovascular related morbidity and mortality, affecting over 8.5 million men and women in the United States and greater than 200 million individuals worldwide. The mainstay of treatment to improve lower limb symptoms is supervised walking therapy, which does not affect plaque morphology or alter conduit artery blood flow, but rather ameliorates endothelial dysfunction, enhances skeletal muscle metabolism and mitochondrial function, and suppresses inflammatory activation. In this pilot feasibility project we will employ metabolic and lipidomic techniques to measure the effects of supervised exercise therapy on primary metabolism, complex lipids, and lipid mediators, and correlate these effects with individual, subject-level measures of the response to exercise therapy among subjects with PAD. The overarching theme of this work is to identify metabolites, complex lipids, and lipid mediators that are associated with the inter-individual variability in the response of subjects with PAD to supervised exercise therapy. This knowledge will significantly enhance our understanding of the pathophysiology of lower extremity symptoms in PAD, as well as the manner in which supervised exercise therapy improves walking intolerance. It will identify novel therapeutic targets and pathways for pharmacologic manipulation in the treatment of PAD. Aside from having the potential to generate multiple high-impact publications, it will serve as the basis for a planned NIH R01 submission by the PI at the conclusion of the award period. |
| Institute: | University of Pennsylvania |
| Department: | Surgery, Perelman School of Medicine |
| Last Name: | Damrauer |
| First Name: | Scott |
| Address: | 3400 Spruce Street, 4 Silverstein Philadelphia, PA 19104 |
| Email: | Scott.Damrauer@uphs.upenn.edu |
| Phone: | 215-615-1698 |
Summary of all studies in project PR000463
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST000659 | Changes in metabolites and lipid mediators associated with supervised exercise training for peripheral | Homo sapiens | University of California, Davis | MS | 2017-10-03 | 1 | 158 | Uploaded data (442.8K)* |
