Summary of project PR000568
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000568. The data can be accessed directly via it's Project DOI: 10.21228/M87T1Q This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR000568 |
| Project DOI: | doi: 10.21228/M87T1Q |
| Project Title: | Camellia nitidissima prevent colorectal cancer |
| Project Type: | Nuclear magnetic resonance-based metabolomics |
| Project Summary: | Colorectal cancer (CRC) is one of the most common malignant tumors worldwide, occurring in the colon or rectum portion of large intestine. With marked antioxidant, anti-inflammation and anti-tumor activities, Camellia nitidissima Chi has been used as an effective treatment of cancer. The azoxymethane/dextran sodium sulfate (AOM/DSS) induced CRC mice model was established and the prevention effect of Camellia nitidissima Chi extracts on the evolving of CRC was evaluated by gross examination, histopathological inspection, serum biochemistry analysis, combined with nuclear magnetic resonance (NMR)-based metabolomics and correlation network analysis. The results showed that Camellia nitidissima Chi extracts could significantly inhibit AOM/DSS induced CRC, relieve the colonic pathology and ameliorate the serum biochemistry, and could significantly reverse the disturbed metabolism towards the normal state. Moreover, the butanol fraction showed a better efficiency than the water-soluble fraction of Camellia nitidissima Chi. The study pave the way for further development of Camellia nitidissima Chi extracts as a potent CRC inhibitor. |
| Institute: | Nanjing University of Science & Technology |
| Department: | Department of Biological Engineering |
| Laboratory: | Center for Molecular Metabolism |
| Last Name: | Li |
| First Name: | Minghui |
| Address: | 200 Xiaolingwei Str., Nanjing, Jiangsu, 210094, China |
| Email: | cpu_lmh@126.com |
| Phone: | +8615952052370 |
Summary of all studies in project PR000568
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST000782 | Nuclear magnetic resonance-based metabolomics approach to evaluate the prevention effect of Camellia nitidissima Chi on colitis-associated carcinogenesis | Mus musculus | Nanjing University of Science & Technology | NMR* | 2017-10-03 | 1 | 126 | Uploaded data (782.6K) |
