Summary of project PR000630

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000630. The data can be accessed directly via it's Project DOI: 10.21228/M87H6H This work is supported by NIH grant, U2C- DK119886.


Project ID: PR000630
Project DOI:doi: 10.21228/M87H6H
Project Title:Metabolomics Linking Air Pollution, Obesity and Type 2 Diabetes
Project Type:NIH/NIEHS P01-ES022845
Project Summary:The overall goal of this proposal is to use blood non-targeted high resolution metabolomics (HRM) to investigate the hypothesis that regional air pollution (NO2, PM2.5 and O3) and traffic-related air pollution exposures (traffic-related particulate matter components including EC2.5 and PM2.5 transition metals, and CALINE model-predicted NOx) alter key metabolic pathway(s) and that these alterations are associated with obesity and type 2 diabetes-related traits during the important developmental period of adolesence in the ongoing prospective Chidlren's Health study (CHS). Specific Aim 1 will examine the adverse impact of environmental chemicals in fasting blood samples measured by HRM on obesity (i.e., total body fat and body mass index (BMI)), metabolic dysfunction (e.g., fasting glucose and insulin concentrations and insulin resistance), and obesity-induced inflammation (i.e., leptin) among 104 Southern California adolescents enrolled in the CHS. Specific Aim 2 will examine associations of childhood exposures to PM2.5 and traffic-related air pollutants (i.e., CALINE model-predicted NOx) with biological metabolites identified in fasting blood samples using HRM among 104 adolescents in the CHS. Specific Aim 3 will investigate the metabolic pathways linking air pollution exposures and obesity and type 2 diabetes-related traits using pathway analysis under bayesian hierarchical model among 104 adolescents in the CHS.
Institute:Emory University
Department:Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine
Laboratory:Clinical Biomarkers Laboratory
Last Name:Walker
First Name:Douglas
Address:615 Michael St. Ste 225, Atlanta, GA, 30322, USA
Phone:(404) 727 5984
Funding Source:NIEHS ES026560
Contributors:Frank Gilliland University of Southern California Keck School of Medicine; Zhanghua Chen University of Southern California Keck School of Medicine; Dean P. Jones, Emory University School of Medicine

Summary of all studies in project PR000630

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST000909 Metabolomics Linking Air Pollution, Obesity and Type 2 Diabetes Homo sapiens Emory University MS* 2020-09-12 1 247 Uploaded data (191.9G)