Summary of project PR000656

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000656. The data can be accessed directly via it's Project DOI: 10.21228/M8W39D This work is supported by NIH grant, U2C- DK119886.


Project ID: PR000656
Project DOI:doi: 10.21228/M8W39D
Project Title:Cereblon suppression offers novel approach for anti-tumor immunity in melanoma
Project Type:Exploratory
Project Summary:The functional suppression of T cells in the tumor are intimately linked to impared cellular metabolism. Glucose acts as the primary fuel source for the generation of ATP in activated T cells and both oxidative phosphorylation and glycolysis are critical for full effector functions and tumor erradication. We have identified a checkpoint protein that regulates the metabolic suppression in the tumor. Identification of the precise function of different metabolic events regulated by this checkpoint protein will be informative. This project will define the role of a glutamine/arginine mediated pathway in CD8+ T-cells.
Institute:Moffitt Cancer Center
Last Name:Burnette
First Name:Pearlie
Address:12902 Magnolia Drive, Tampa, FL 33612
Funding Source:Moffitt Cancer Center

Summary of all studies in project PR000656

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST000955 Effects of ODC inhibition on T cell metabolism Mus musculus University of Florida MS* 2019-05-15 1 48 Uploaded data (25.8G)*