Summary of project PR000656
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000656. The data can be accessed directly via it's Project DOI: 10.21228/M8W39D This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR000656 |
| Project DOI: | doi: 10.21228/M8W39D |
| Project Title: | Cereblon suppression offers novel approach for anti-tumor immunity in melanoma |
| Project Type: | Exploratory |
| Project Summary: | The functional suppression of T cells in the tumor are intimately linked to impared cellular metabolism. Glucose acts as the primary fuel source for the generation of ATP in activated T cells and both oxidative phosphorylation and glycolysis are critical for full effector functions and tumor erradication. We have identified a checkpoint protein that regulates the metabolic suppression in the tumor. Identification of the precise function of different metabolic events regulated by this checkpoint protein will be informative. This project will define the role of a glutamine/arginine mediated pathway in CD8+ T-cells. |
| Institute: | Moffitt Cancer Center |
| Department: | Immunology |
| Laboratory: | Burnette |
| Last Name: | Burnette |
| First Name: | Pearlie |
| Address: | 12902 Magnolia Drive, Tampa, FL 33612 |
| Email: | Pearlie.Burnette@moffitt.org |
| Phone: | 813-270-9181 |
| Funding Source: | Moffitt Cancer Center |
Summary of all studies in project PR000656
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST000955 | Effects of ODC inhibition on T cell metabolism | Mus musculus | University of Florida | MS* | 2019-05-15 | 1 | 48 | Uploaded data (25.8G)* |
