Summary of project PR000662

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000662. The data can be accessed directly via it's Project DOI: 10.21228/M83Q2T This work is supported by NIH grant, U2C- DK119886.


Project ID: PR000662
Project DOI:doi: 10.21228/M83Q2T
Project Title:Integrated in vivo quantitative proteomics and nutrient tracing reveals age-related metabolic rewiring of pancreatic beta cell function
Project Summary:Aging is associated with fundamental changes in pancreatic β-cell physiology; yet, the mechanisms that drive these age-related changes are poorly understood. Here, we performed comprehensive in vivo quantitative proteomic profiling of pancreatic islets from adolescent and old mice. Nutrient tracing and targeted metabolomics demonstrated accelerated accumulation of glucose-derived metabolites and coupling factors in aged islets, indicating that age-related changes in glucose metabolism contribute to improved glucose-stimulated insulin secretion with age. Together, our study provides the first in-depth characterization of age-related changes in the islet proteome and establishes metabolic rewiring as an important mechanism for age-associated changes in β-cell function.
Institute:University of California, San Diego
Last Name:Wortham
First Name:Matthew
Address:2880 Torrey Pines Scenic Drive, Sanford Consortium for Regenerative Medicine, Room 3102, La Jolla, California, 92037, USA

Summary of all studies in project PR000662

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST000964 U13C Glucose Tracing of Young and Old Pancreatic Islets Mus musculus University of California, San Diego MS 2019-04-27 1 20 Uploaded data (349.3M)*
ST000965 Timecourse of U13C glucose labeling of pancreatic islets in young mice Mus musculus University of California, San Diego MS 2019-04-27 1 27 Uploaded data (300.9M)*