Summary of project PR000683
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000683. The data can be accessed directly via it's Project DOI: 10.21228/M8D11B This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR000683 |
| Project DOI: | doi: 10.21228/M8D11B |
| Project Title: | Mayo Pilot and Feasibility: Characterization of metabolomics profile changes during development of post-traumatic epilepsy |
| Project Summary: | According to the report from the Centers for Disease Control and Prevention in 2014, traumatic brain injury (TBI) accounts for 30% of all injury-related deaths in the U.S. Developing epilepsy after severe head injury is as high as 40%-50% in some settings. Importantly, many TBI victims develop epilepsy months or years following the initial injury. However, it has not been fully identified how to predict who will develop epilepsy and/or the underlying mechanism of post traumatic epilesy (PTE) development. The main goal of this proposal is to identify the metabolomics biomarker of TBI-induced epilepsy and to investigate the underlying mechanism of the transition from TBI to PTE. To do so, we will develop PTE using two TBI animal models: ferrous chloride injection model and cortical undercut model. Once the brain damage is made, electroencephalogram (EEG) and video monitoring will be performed to determine the onset point of epilepsy. Then, metabolomics profile changes will be analyzed and compared before and after PTE development. |
| Institute: | Mayo Clinic |
| Last Name: | Su-youne |
| First Name: | Chang |
| Address: | 200 1st Street SW Rochester, MN 55905, USA |
| Email: | Chang.SuYoune@mayo.edu |
| Phone: | 1-507-293-0511 |
Summary of all studies in project PR000683
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST001020 | Characterization of metabolomics profile changes during development of post-traumatic epilepsy in Rat Plasma (part-I) | Rattus norvegicus | Mayo Clinic | MS* | 2020-07-15 | 1 | 108 | Uploaded data (8.8M) |
| ST001021 | Characterization of metabolomics profile changes during development of post-traumatic epilepsy in Rat Cerebrospinal Fluid (part-II) | Rattus norvegicus | Mayo Clinic | MS* | 2020-07-15 | 1 | 48 | Uploaded data (1.1M) |
| ST001022 | Characterization of metabolomics profile changes during development of post-traumatic epilepsy in Rat Brain Tissue (part-III) | Rattus norvegicus | Mayo Clinic | MS* | 2020-07-15 | 1 | 160 | Uploaded data (4.3M) |
