Summary of project PR000769

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000769. The data can be accessed directly via it's Project DOI: 10.21228/M88T11 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Project ID: PR000769
Project DOI:doi: 10.21228/M88T11
Project Title:Metabolomics of a Mouse Model for Retinitis Pigmentosa
Project Summary:Retinitis pigmentosa (RP) is a degenerative disease of the retina that affects approximately 1 million people worldwide. There are multiple genetic causes of this disease, for which, at present, there are no effective therapeutic strategies. We utilized broad spectrum metabolomics to identify perturbations in the metabolism of the rd10 mouse, a genetic model for RP. C57BL/6J and rd10 mice were raised in cyclic light followed by either light or dark adaptation at postnatal day (P) 18, an early stage in the degeneration process. Mice raised entirely in the dark until P18 were also evaluated. After euthanasia, retinas were removed and extracted for analysis by ultra-performance liquid chromatography-time of flight-mass spectrometry (UPLC-QTOF-MS).
Institute:University of North Carolina
Laboratory:ERCMRC
Last Name:Sumner
First Name:Susan
Address:NRI, 500 Laureate Way, Kannapolis, NC, 28081, USA
Email:susan_sumner@unc.edu
Phone:704-250-5066
Funding Source:NIDDK U24DK097193 (Sumner, PI); Supplement to NEI R01EY12224 (Weiss, PI)

Summary of all studies in project PR000769

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)		 Release
Date		VersionSamplesDownload
(* : Contains raw data)
ST001150 Metabolomics of a Mouse Model for Retinitis Pigmentosa Mus musculus University of North Carolina at Chapel Hill MS* 2019-07-17 1 37 Uploaded data (2.8M)
  logo