Summary of project PR000828
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000828. The data can be accessed directly via it's Project DOI: 10.21228/M8NQ4J This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR000828 |
| Project DOI: | doi: 10.21228/M8NQ4J |
| Project Title: | Metabolomic adaptations and correlates of survival to immune checkpoint blockade |
| Project Type: | Serum metabolomcs |
| Project Summary: | To investigate the metabolic alterations in response to immune checkpoint blockade, we comprehensively profiled serum metabolites in advanced melanoma and renal cell carcinoma patients treated with nivolumab, an antibody against programmed cell death protein 1 (PD1). We identified serum kynurenine/tryptophan ratio increases as an adaptive resistance mechanism associated with worse overall survival. This advocates for patient stratification and metabolic monitoring in immunotherapy clinical trials including those combining PD1 blockade with IDO/TDO inhibitors. |
| Institute: | Broad Institute of MIT and Harvard |
| Department: | Metabolomics Platform |
| Last Name: | Clish |
| First Name: | Clary |
| Address: | 415 Main Street, Cambridge, MA, 02142, USA |
| Email: | clary@broadinstitute.org |
| Phone: | 617-714-7654 |
| Funding Source: | Conquer Cancer Foundation ASCO Career Development Award; Stand Up To Cancer Colorectal Cancer Dream Team Translational Research Grant (grant number: SU2C-AACR-DT22-17); the Dana-Farber/Harvard Cancer Center Kidney Cancer program; NCI's Cancer Target Discovery and Development (CTD2) Network (grant number: U01CA217848); Kidney SPORE P50CA101942-12; the Trust Family, Michael Brigham, and Loker Pinard Funds for Kidney Cancer Research at Dana-Farber Cancer Institute; the BMS II-ON consortium; and the AACR KureIt Grant for Kidney Cancer. |
| Contributors: | Haoxin Li, Kevin Bullock, Carino Gurjao, David Braun, Sachet Shukla, Dominick Bossé, Aly-Khan A. Lalani, Shuba Gopal, Chelsea Jin, Christine Horak, Megan Wind-Rotolo, Sabina Signoretti, David F. McDermott, Gordon J. Freeman, Eliezer M. Van Allen, Stuart L. Schreiber, F. Stephen Hodi, William R. Sellers, Levi A. Garraway, Clary Clish, Toni K. Choueiri, Marios Giannakis |
Summary of all studies in project PR000828
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST001235 | Metabolic responses to PD1 immune-checkpoint blockade and association with therapeutic benefits - Part I | Homo sapiens | Broad Institute of MIT and Harvard | MS | 2019-08-27 | 1 | 212 | Uploaded data (402.6M)* |
| ST001236 | Metabolic responses to PD1 immune-checkpoint blockade and association with therapeutic benefits - Part II | Homo sapiens | Broad Institute of MIT and Harvard | MS | 2019-08-27 | 1 | 244 | Uploaded data (35.3G)* |
| ST001237 | Metabolic responses to PD1 immune-checkpoint blockade and association with therapeutic benefits - Part III | Homo sapiens | Broad Institute of MIT and Harvard | MS | 2019-08-27 | 1 | 1221 | Uploaded data (149.1G)* |
