Summary of project PR000882

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000882. The data can be accessed directly via it's Project DOI: 10.21228/M8PD88 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Project ID: PR000882
Project DOI:doi: 10.21228/M8PD88
Project Title:Luminal metabolome profiles of human microbiota-associated (HMA) mice treated with anti-IL-22 antibody or control antibody
Project Summary:We found that healthy (HC)-HMA mice, GF mice were colonized with gut microbiota derived from human HC, were protected from Clostridioides difficile (C. difficile) infection. However, the colonization resistance of HC-HMA mice was abolished by treatment of anti-IL-22 antibody, unlike control antibody-treated HC-HMA mice. Additionally, the gut microbial composition of anti-IL22 antibody-treated HC-HMA mice, C. difficile-susceptible mice, were differ from that of control antibody, thereby it appears that luminal metabolome is changed between 2 groups. To examine the change in the luminal metabolites, fecal samples were collected from anti-IL-22 /control -antibody treated HC-HMA mice, and metabolite profiles of them were analyzed.
Institute:University of Michigan
Department:Internal Medicine
Last Name:Kamada
First Name:Nobuhiko
Address:1150 W Medical center Dr, Ann Arbor, MI 48109, USA
Email:nkamada@umich.edu
Phone:+1-734-763-2142

Summary of all studies in project PR000882

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)		 Release
Date		VersionSamplesDownload
(* : Contains raw data)
ST001301 Luminal metabolome profiles of human microbiota-associated (HMA) mice treated with anti-IL-22 antibody or control antibody Mus musculus University of Michigan MS 2020-01-08 1 26 Uploaded data (10.7G)*
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