Summary of project PR000915
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000915. The data can be accessed directly via it's Project DOI: 10.21228/M8DQ2M This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR000915 |
| Project DOI: | doi: 10.21228/M8DQ2M |
| Project Title: | Disruption of Redox Balance Enhances the Effects of BRAF-inhibitors in Melanoma |
| Project Type: | Untargeted-Targeted Metabolomics analysis |
| Project Summary: | Melanomas harboring BRAF mutations can be treated with BRAF inhibitors, but tumor recurrence is inevitable. In spite of large-scale attempts, there remains an unmet need to uncover molecular determinants of BRAFi insensitivity and devise actionable combination targets to overcome resistance. Here, using an integrative approach of experimentation, and mathematical flux balance analyses in a panel of BRAF-mutated melanoma cells, we show that elevated antioxidant capacity of melanoma cells is linked to their drug sensitivity. Specifically, we report that drug-insensitive melanoma cells can maintain higher levels of antioxidant metabolites to withstand the lethal effects of drugs. By extending our analysis to other melanoma subtypes in the TCGA, we show that elevated redox capacity could indeed be a general feature of melanoma. Our results suggest that redox vulnerabilities could be exploited for therapeutic benefits and identify unsuspected combination targets to enhance the effects of BRAFi in pan-melanoma. |
| Institute: | Vanderbilt University |
| Last Name: | Codreanu |
| First Name: | Simona |
| Address: | 1234 Stevenson Center Lane |
| Email: | simona.codreanu@vanderbilt.edu |
| Phone: | 6158758422 |
Summary of all studies in project PR000915
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST001339 | Disruption of Redox Balance Enhances the Effects of BRAF-inhibitors in Melanoma | Homo sapiens | Vanderbilt University | MS* | 2021-03-31 | 1 | 40 | Uploaded data (5.7G)* |
