Summary of project PR000924

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000924. The data can be accessed directly via it's Project DOI: 10.21228/M8810Q This work is supported by NIH grant, U2C- DK119886.


Project ID: PR000924
Project DOI:doi: 10.21228/M8810Q
Project Title:48 hours Post-treatment L-Carnitine Pharmacometabolomics in Sepsis (CaPS) Study
Project Type:Quantitative NMR Metabolomics
Project Summary:To utilize existing serum samples from the phase II clinical trial of L-carnitine treatment for severe sepsis to metabolically phenotype L-carnitine responders and non-responders. Methods: Serum samples collected prior to (T0) and after completion of the infusion (T24, T48) from patients randomized to either low (6 g), intermediate (12g), high (18g) L-carnitine or placebo for the treatment of vasopressor dependent septic shock were assayed by untargeted 1H-nuclear magnetic resonance metabolomics.
Institute:University of Michigan
Laboratory:Stringer NMR Metabolomics Laboratory
Last Name:McHugh
First Name:Cora
Address:428 Church St, Ann Arbor, MI, 48103, USA
Funding Source:GM111400
Contributors:Michael A. Puskarich, Cora McHugh, Alla Karnovsky, Alan E. Jones, Kathleen A. Stringer

Summary of all studies in project PR000924

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST001354 48 hours post-treatment L-Carnitine Pharmacometabolomics in Sepsis (CaPS) Patients Homo sapiens University of Michigan NMR 2020-07-05 1 180 Uploaded data (33.1M)*