Summary of project PR000952
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000952. The data can be accessed directly via it's Project DOI: 10.21228/M8N397 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR000952 |
| Project DOI: | doi: 10.21228/M8N397 |
| Project Title: | Enteric microbiota and liver metabolomics during the postnatal period |
| Project Summary: | Following birth, the neonatal intestine is exposed to maternal and environmental bacteria that successively form a dense and highly dynamic intestinal microbiota. Whereas the effect of exogenous factors has been extensively investigated, endogenous, host-mediated mechanisms have remained largely unexplored. Concomitantly with microbial colonization, the liver undergoes functional transition from a hematopoietic organ to a central organ of metabolic regulation and immune surveillance. The aim of the present study was to analyze the influence of the developing hepatic function and liver metabolism on the early intestinal microbiota. Using metabolomic and microbial profiling in combination with multivariate analysis we characterized the colonization dynamics and liver metabolism in the murine gastrointestinal tract (n=6-10 per age group). We observed major age-dependent microbial and metabolic changes and identified bile acids as potent drivers of the early intestinal microbiota maturation. Consistently, oral administration of tauro-cholic acid or β-tauro-murocholic acid to newborn mice (n= 7-14 per group) accelerated postnatal microbiota maturation. |
| Institute: | Helmholtz Centre for Environmental Research - UFZ |
| Last Name: | Haange |
| First Name: | Sven |
| Address: | Permoserstrasse 1, Leipzig, Saxony, 04318, Germany |
| Email: | sven.haange@ufz.de |
| Phone: | 0049 341 2351099 |
Summary of all studies in project PR000952
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST001388 | Quantitative bile acids study on total murine liver tissue from mice at different age | Mus musculus | Helmholtz Centre for Environmental Research | MS | 2020-06-10 | 1 | 27 | Uploaded data (1.8M)* |
| ST001389 | Quantitative amino acids and biogenic amines study on total murine liver tissue from mice at different age | Mus musculus | Helmholtz Centre for Environmental Research | MS | 2020-06-10 | 1 | 28 | Uploaded data (1.5M)* |
| ST001396 | Quantitative Lipids study on total murine liver tissue from mice at different age | Mus musculus | Helmholtz Centre for Environmental Research | MS | 2020-06-10 | 1 | 28 | Uploaded data (720.1K)* |
| ST001397 | Quantitative Hexose study on total murine liver tissue from mice at different age | Mus musculus | Helmholtz Centre for Environmental Research | MS | 2020-06-10 | 1 | 28 | Uploaded data (957.6K)* |
