Summary of project PR000978

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000978. The data can be accessed directly via it's Project DOI: 10.21228/M88Q44 This work is supported by NIH grant, U2C- DK119886.


Project ID: PR000978
Project DOI:doi: 10.21228/M88Q44
Project Title:Influence of growth medium on the volatilomes of Pseudomonas spp. and Staphylococcus spp.
Project Type:Untargeted MS
Project Summary:Pseudomonas aeruginosa and Staphylococcus aureus are the predominant opportunistic lung pathogens persons with CF [2017 CF Foundation Annual Report] and are leading causes of respiratory failure and mortality [Malhotra, et al. Clin Microbiol Rev, 2019]. Currently, sputum culture remains the standard of care for lung infection detection, but sputum production is on the decline due to improvements in CF therapies. To fill this diagnostic gap, we are working toward the development of breath tests for lung infections by characterizing the volatile metabolome (or “volatilome”) of P. aeruginosa and S. aureus. In this study, we explored the influence of growth medium on the volatilomes of two strains of P. aeruginosa (PAO1 and PA14) and S. aureus, as well as two other species from the same genera, S. epidermidis and P. chlororaphis. We hypothesized that the volatilomes would be influenced by the growth medium, but that biological differences between these species and strains would dominate the volatilomes and facilitate identification.
Institute:Arizona State University
Department:School of Life Sciences
Laboratory:Heather D. Bean Lab
Last Name:Bean, Ph.D.
First Name:Heather
Address:PO Box 874501 Tempe, AZ 85287
Publications:Jenkins, C. L., H. D. Bean (2020). Influence of media on the differentiation of Staphylococcus spp. by volatile compounds. Journal of breath research 14, 016007 doi:10.1088/1752-7163/ab3e9d

Summary of all studies in project PR000978

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST001426 Dependence of the Staphylococcal Volatilome Composition on Microbial Nutrition Staphylococcus epidermidis Arizona State University MS* 2020-07-30 1 77 Uploaded data (7.3G)*