Summary of project PR000997
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000997. The data can be accessed directly via it's Project DOI: 10.21228/M8TH75 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR000997 |
| Project DOI: | doi: 10.21228/M8TH75 |
| Project Title: | ACSL1 role in conjugated PUFA metabolism |
| Project Type: | MS quantitative lipidomic study |
| Project Summary: | Ferroptosis is associated with lipid hydroperoxides generated by oxidation of polyunsaturated acyl chains. Lipid hydroperoxides are reduced by glutathione peroxidase 4 (GPX4) and GPX4 inhibitors induce ferroptosis. However, the therapeutic potential of triggering ferroptosis in cancer cells with polyunsaturated fatty acids is unknown. We identified conjugated linoleates including α-eleostearate (αESA) as novel ferroptosis inducers. αESA did not alter GPX4 activity but was incorporated into cellular lipids and promoted lipid peroxidation and cell death in diverse cancer cell types. αESA-triggered death was mediated by acyl-CoA synthetase long-chain isoform 1, which promoted αESA incorporation into neutral lipids including triacylglycerols. Interfering with triacylglycerol biosynthesis suppressed ferroptosis triggered by αESA. |
| Institute: | Fox Chase Cancer Center |
| Last Name: | Peterson |
| First Name: | Jeffrey |
| Address: | 333 Cottman Avenue, Philadelphia, PA, 19111, USA |
| Email: | Jeffrey.peterson@fccc.edu |
| Phone: | 215-728-3568 |
| Funding Source: | DOD, NIH |
| Publications: | in process |
| Contributors: | Valarian Kagan |
Summary of all studies in project PR000997
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST001451 | Eleostearic acid effects on TAGs and oxLipids | Homo sapiens | Fox Chase Cancer Center | MS | 2020-09-10 | 1 | 47 | Uploaded data (5.2G)* |
