Summary of project PR001017
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001017. The data can be accessed directly via it's Project DOI: 10.21228/M87M4S This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001017 |
| Project DOI: | doi: 10.21228/M87M4S |
| Project Title: | Hepatic [U-13C]Lactate tracing and metabolomics in young and old WT and SIRT6 overexpressing mice |
| Project Type: | MS analysis |
| Project Summary: | Our previous data had suggested that gluconeogenesis capacity from the precursors lactate and glycerol declines in old C57BL/6 mice. This decline was rescued by whole body SIRT6 overexpression. Since the liver is the main gluconeogenic organ, we performed here liver metabolomics in young (6 months) versus old (20-24 months) WT and SIRT6-transgenic mice. We used liver tissues of 6h morning-fasted mice, either in naïve state or 15 minutes after intraperitoneal injection of [U-13C]Lactate. |
| Institute: | Bar Ilan University |
| Department: | The Mina & Everard Goodman Faculty of Life Sciences |
| Laboratory: | Laboratory of Prof. Haim Cohen |
| Last Name: | Cohen |
| First Name: | Chaim |
| Address: | Ramat Gan, Ramat Gan, Israel, 5290002, Israel |
| Email: | Haim.Cohen@biu.ac.il |
| Phone: | +97235318383 |
| Funding Source: | Israel Science Foundation (621/13 and 777/16), I-Core foundation (1775/12) and (41/11) and Laura and Isaac Perlmutter Foundation |
| Contributors: | Asael Roichman, Ifat Abramovich, Eyal Gottlieb, Haim Yosef Cohen |
Summary of all studies in project PR001017
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST001507 | Hepatic [U-13C]Lactate tracing and metabolomics in young and old WT and SIRT6 overexpressing mice | Mus musculus | Bar Ilan University | MS | 2021-03-11 | 1 | 119 | Uploaded data (10.5G)* |
| ST001508 | Liver metabolomics in old liver-specific SIRT6 overexpressing mice | Mus musculus | Bar Ilan University | MS | 2021-03-11 | 1 | 20 | Uploaded data (1.5G)* |
