Summary of project PR001017

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001017. The data can be accessed directly via it's Project DOI: 10.21228/M87M4S This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Project ID: PR001017
Project DOI:doi: 10.21228/M87M4S
Project Title:Hepatic [U-13C]Lactate tracing and metabolomics in young and old WT and SIRT6 overexpressing mice
Project Type:MS analysis
Project Summary:Our previous data had suggested that gluconeogenesis capacity from the precursors lactate and glycerol declines in old C57BL/6 mice. This decline was rescued by whole body SIRT6 overexpression. Since the liver is the main gluconeogenic organ, we performed here liver metabolomics in young (6 months) versus old (20-24 months) WT and SIRT6-transgenic mice. We used liver tissues of 6h morning-fasted mice, either in naïve state or 15 minutes after intraperitoneal injection of [U-13C]Lactate.
Institute:Bar Ilan University
Department:The Mina & Everard Goodman Faculty of Life Sciences
Laboratory:Laboratory of Prof. Haim Cohen
Last Name:Cohen
First Name:Chaim
Address:Ramat Gan, Ramat Gan, Israel, 5290002, Israel
Email:Haim.Cohen@biu.ac.il
Phone:+97235318383
Funding Source:Israel Science Foundation (621/13 and 777/16), I-Core foundation (1775/12) and (41/11) and Laura and Isaac Perlmutter Foundation
Contributors:Asael Roichman, Ifat Abramovich, Eyal Gottlieb, Haim Yosef Cohen

Summary of all studies in project PR001017

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
Release
Date
VersionSamplesDownload
(* : Contains raw data)
ST001507 Hepatic [U-13C]Lactate tracing and metabolomics in young and old WT and SIRT6 overexpressing mice Mus musculus Bar Ilan University MS 2021-03-11 1 119 Uploaded data (10.5G)*
ST001508 Liver metabolomics in old liver-specific SIRT6 overexpressing mice Mus musculus Bar Ilan University MS 2021-03-11 1 20 Uploaded data (1.5G)*
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