Summary of project PR001032

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001032. The data can be accessed directly via it's Project DOI: 10.21228/M89D63 This work is supported by NIH grant, U2C- DK119886.


Project ID: PR001032
Project DOI:doi: 10.21228/M89D63
Project Title:Genetic background shapes phenotypic response to diet for adiposity in the Collaborative Cross
Project Summary:Defined as chronic excessive accumulation of adiposity, obesity results from long-term imbalance between energy intake and expenditure. The mechanisms behind how caloric imbalance occurs are complex and influenced by numerous biological and environmental factors, especially genetics and diet. Population-based diet recommendations have had limited success partly due to the wide variation in physiological responses across individuals when they consume the same diet. Thus, it is necessary to broaden our understanding of how individual genetics and diet interact relative to the development of obesity for improving weight loss treatment. To determine how consumption of diets with different macronutrient composition alter adiposity and other obesity-related traits in a genetically diverse population, we analyzed body composition, metabolic rate, clinical blood chemistries, and circulating metabolites in 22 strains of mice from the Collaborative Cross (CC), a highly diverse recombinant inbred mouse population, before and after 8 weeks of feeding either a high protein or high fat high sucrose diet. At both baseline and post-diet, adiposity and other obesity-related traits exhibited a broad range of phenotypic variation based on CC strain; diet-induced changes in adiposity and other traits also depended largely on CC strain. In addition to estimating heritability at baseline, we also quantified the effect size of diet for each trait, which varied by trait and experimental diet. Our findings identified CC strains prone to developing obesity, demonstrate the genotypic and phenotypic diversity of the CC for studying complex traits, and highlight the importance of accounting for genetic differences when making dietary recommendations.
Department:Obesity and metabolism research unit
Laboratory:Bennett's Lab
Last Name:Bennett
First Name:Brian
Address:430 West Health Sciences Drive, DAVIS, CA, 95616, USA
Phone:(530) 754-4417

Summary of all studies in project PR001032

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST001607 Genetic background shapes phenotypic response to diet for adiposity in the Collaborative Cross Mus musculus USDA MS 2020-12-31 1 400 Uploaded data (67.6M)*