Summary of project PR001038

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001038. The data can be accessed directly via it's Project DOI: 10.21228/M8HX30 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Project ID: PR001038
Project DOI:doi: 10.21228/M8HX30
Project Title:Metabolomics Analysis: Opioid Addiction Project
Project Summary:Drug addiction is a major threat to the public health in the US and many other countries. Opioid abuse is associated with increased risks for cancer, psychological complications, heart and lung disease, and infections of the liver and blood. Because metabolites are intrinsically involved in multiple metabolic pathways in vivo, the relative quantification of metabolites in body fluids (for example urine) can provide a profile of the metabolic state of an organism. Metabolomics is a powerful technique for revealing the impact of exposure on the overall biochemistry of an individual or system. Opioids can modify the output of urinary metabolites through many integrated neural and hormonal mechanisms within the periphery, central nervous system, and kidneys. Opioids modulate the expression of genes involved in neuroplasticity through epigenetic and possibly RNA modifications, ultimately change the intracellular signaling cascades and dysfunction, and cause long-lasting changes in metabolome. The objective of this study is to identify how opium impacts metabolic pathways to provide markers of abuse, long-term opium addiction, the addiction molecular pathway, and unknown metabolites that are important to differentiation of the study phenotypes. To reach these goals in the present study, the urine specimens of opium abusers and non-users as controls was profiled using an untargeted nuclear magnetic resonance spectroscopy (NMR) metabolomics, and a quantitative targeted liquid chromatography mass spectrometric (LC-MS/MS) at University of North Carolina at Chapel Hill. The Golestan Cohort Study is conducted in Northeast of Iran to primarily study the risk factors for upper gastrointestinal cancers in this high-risk region, in which about 50,000 volunteers were analyzed for opium users and their mortality. More than 8,000 of participants (17%) age 40-75 reported opium use with a mean duration of 12.7 years. Opium was either smoked or orally consumed. The participants were selected from the cohort stratified by opium use patterns and tobacco use.
Institute:University of North Carolina at Chapel Hill
Laboratory:UNC-NRI Sumner Lab
Last Name:Sumner
First Name:Susan
Address:500 Laureate Way, Kannapolis, NC, 28081, USA
Email:susan_sumner@unc.edu
Phone:919-622-4456
Publications:1. Untargeted Metabolomics: Biochemical Perturbations in Golestan Cohort Study Opium Users Inform Intervention Strategies: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783045/
2. Metabolomics reveals biomarkers of opioid use disorder: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862627/

Summary of all studies in project PR001038

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
Release
Date
VersionSamplesDownload
(* : Contains raw data)
ST001618 Metabolomics Analysis: Opioid Addiction Project (Golestan Cohort Study) - MS (part-I) Homo sapiens University of North Carolina at Chapel Hill MS* 2021-11-24 1 336 Uploaded data (35.3G)*
ST001619 Metabolomics Analysis: Opioid Addiction Project (Golestan Cohort Study) - NMR (part-II) Homo sapiens University of North Carolina at Chapel Hill NMR 2021-11-24 1 334 Uploaded data (118.6M)*
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