Summary of project PR001039
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001039. The data can be accessed directly via it's Project DOI: 10.21228/M8D400 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001039 |
| Project DOI: | doi: 10.21228/M8D400 |
| Project Title: | Unique metabolomic profile of skeletal muscle in chronic limb threatening ischemia |
| Project Type: | NMR |
| Project Summary: | This project is focused on a cross-sectional analysis of non-PAD controls and CLTI patients undergoing either a vascular intervention or undergoing limb amputation was performed and involved a detailed assessment of the limb muscle metabolome using HR-MAS and solution state NMR spectroscopy. It was hypothesized that patients undergoing limb amputation would present with altered muscle metabolite features compared with non-PAD controls. |
| Institute: | University of Florida |
| Department: | Applied Physiology and Kinesiology |
| Laboratory: | Rm 42 and Rm 43 |
| Last Name: | Ryan |
| First Name: | Terence |
| Address: | University of Florida, Applied Physiology and Kinesiology, 1864 stadium RD, Gainesville, FL 32611 |
| Email: | ryant@ufl.edu |
| Phone: | 352-294-1700 |
| Funding Source: | National Institutes of Health and the National Heart, Lung, and Blood, Institute numbers R01-HL149704 (to T.E.R.) and R01-HL148597 (to S.T.S.); as well as the American Heart Association grant number 18CDA34110044 (to T.E.R.). A portion of this work was supported by pilot funds (awarded to T.E.R.) from The University of Florida Claude D. Pepper Older Americans Independence Center P30AG028740. (if applicable) |
| Project Comments: | PAD metabolomic study via NMR. A detailed assessment of the limb muscle metabolome using semi-solid and solution state NMR spectroscopy. |
| Publications: | Journal of Clinical Medicine |
| Contributors: | Ram B. Khattri, Kyoungrae Kim, Trace Thome, Zachary R. Salyers, Kerri A. O’Malley, Scott A. Berceli, Salvatore T. Scali, Terence E. Ryan* |
Summary of all studies in project PR001039
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST001615 | Unique metabolomic profile of skeletal muscle in chronic limb threatening ischemia (organic phase samples) | Homo sapiens | University of Florida | NMR | 2021-05-30 | 1 | 24 | Uploaded data (16.7M)* |
| ST001616 | Unique metabolomic profile of skeletal muscle in chronic limb threatening ischemia (aqueous phase samples ) | Homo sapiens | University of Florida | NMR | 2021-05-30 | 1 | 24 | Uploaded data (16.8M)* |
| ST001617 | Unique metabolomic profile of skeletal muscle in chronic limb threatening ischemia (HR-MAS study) | Homo sapiens | University of Florida | NMR | 2022-07-07 | 1 | 25 | Uploaded data (46.4M)* |
