Summary of project PR001041
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001041. The data can be accessed directly via it's Project DOI: 10.21228/M84M6M This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001041 |
| Project DOI: | doi: 10.21228/M84M6M |
| Project Title: | Dietary composition analysis studies |
| Project Type: | Untargeted metabolomics analysis with two diets |
| Project Summary: | Dietary patterns and psychosocial factors, ubiquitous part of modern lifestyle, critically shape the gut microbiota and human health. However, it remains obscure how dietary and psychosocial inputs coordinately modulate the gut microbiota and host impact. Here, we show that dietary raffinose metabolism to fructose couples stress-induced gut microbial remodeling to intestinal stem cells (ISC) renewal and epithelial homeostasis. Chow diet (CD) and purified diet (PD) confer distinct vulnerability to gut epithelial injury, microbial alternation and ISC dysfunction in chronically restrained mice. CD preferably enriches Lactobacillus reuteri, and its colonization is sufficient to rescue stress-triggered epithelial injury. |
| Institute: | China Pharmaceutical University |
| Department: | School of Medicine |
| Laboratory: | metabonomics |
| Last Name: | Yunalong |
| First Name: | Hou |
| Address: | Nanjing, Jiangsu |
| Email: | jian2103@163.com |
| Phone: | 18851105337 |
Summary of all studies in project PR001041
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST001620 | Dietary composition analysis of chow diet and purified diet using untargeted metabonomics | - | China Pharmaceutical University | MS | 2020-12-16 | 1 | 7 | Uploaded data (1.6G)* |
| ST001621 | Untargeted metabolomics of intestinal organoids treated with fructose | Mus musculus | China Pharmaceutical University | MS | 2020-12-16 | 1 | 6 | Uploaded data (612.6M)* |
| ST001622 | Isotope Tracing Analysis in Intestinal Organoids with fructose | Mus musculus | China Pharmaceutical University | MS | 2020-12-16 | 1 | 6 | Uploaded data (1.3G)* |
| ST001623 | Targeted metabolomics analysis with raffinose-rich diet in mouse ileum | Mus musculus | China Pharmaceutical University | MS | 2020-12-16 | 1 | 15 | Uploaded data (4.6G)* |
