Summary of project PR001060

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001060. The data can be accessed directly via it's Project DOI: 10.21228/M8PH55 This work is supported by NIH grant, U2C- DK119886.


Project ID: PR001060
Project DOI:doi: 10.21228/M8PH55
Project Title:Investigation of infection-tolerance phenomenon in mammalian reservoir of Lyme disease, Peromyscus leucopus
Project Type:Comparative study of Peromyscus leucopus and Mus musculus, BALB/c, metabolic response to endotoxin treatment
Project Summary:Infection-tolerance mechanism were investigated in a natural reservoir of Lyme disease, Peromyscus leucopus, white-footed deermice following exposure of a single dose of lipopolysaccharide endotoxin. The multiparametric responses of this treatment were compared to widely used mouse model, Mus musculus BALB/c. Following LPS and saline treatment, samples from blood, spleen and liver tissues were collected postmortem from both animals and subjected to RNA-seq, untargeted metabolomics and specific RT-qPCR.
Institute:Colorado State University
Department:Microbiology, Immunology and Pathology
Laboratory:Belisle Lab
Last Name:Nurul
First Name:Islam
Address:3185 Rampart Road, Fort Collins, CO 80521
Phone:970 492 4249
Funding Source:NIH and the Office of the Assistant Secretary of Defense for Health Affairs through the Tick Borne Disease Research Program
Project Comments:N/A
Contributors:Gabriela Balderrama Gutierrez, Ana Milovic, Vanessa J. Cook, M. Nurul Islam, Youwen Zhang, Hippokratis Kiaris, John T. Belisle, Ali Mortazavi and Alan G. Barbour.

Summary of all studies in project PR001060

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST001654 Metabolic profiling of plasma collected from Peromyscus leucopus and Mus musculus following LPS treatment Mus musculus;Peromyscus leucopus Colorado State University MS* 2021-03-15 1 47 Uploaded data (4.5G)*